De Maria Beatrice, Parati Monica, Bey Yagis, Dalla Vecchia Laura Adelaide, Perego Francesca
Department of Internal Medicine, Istituti Clinici Scientifici Maugeri IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Milan, ITA.
Cureus. 2024 Mar 19;16(3):e56449. doi: 10.7759/cureus.56449. eCollection 2024 Mar.
Autonomic nervous system (ANS) regulation in hereditary angioedema (HAE) and coronavirus disease 2019 (COVID-19) is unknown. ANS alterations could be manifested during both the acute and post-acute phases of COVID-19. Implications of acute and chronic inflammation on ANS in HAE need to be addressed. In this case report, we monitored the systolic arterial blood pressure variability and baroreflex sensitivity in a female HAE patient both before experiencing COVID-19 symptoms and one month afterward. We also tracked the heart rate variability on the day preceding symptom onset, the day of symptom onset (SYM), the day following SYM, five days after SYM, the day of the first negative nasopharyngeal swab (i.e., 12 days after SYM), and one month after symptom onset. The results of this case report provide the characterization of vascular and cardiac autonomic profiles in an HAE patient until the resolution of an acute infection, a potential trigger for the acute HAE attack.
遗传性血管性水肿（HAE）和2019冠状病毒病（COVID-19）中自主神经系统（ANS）的调节尚不清楚。ANS改变可能在COVID-19的急性期和急性后期均有表现。需要探讨急性和慢性炎症对HAE中ANS的影响。在本病例报告中，我们监测了一名女性HAE患者在出现COVID-19症状之前和之后一个月的收缩期动脉血压变异性和压力反射敏感性。我们还追踪了症状发作前一天、症状发作当天（SYM）、SYM后一天、SYM后五天、首次鼻咽拭子阴性当天（即SYM后12天）以及症状发作后一个月的心率变异性。本病例报告的结果提供了一名HAE患者直至急性感染（急性HAE发作的潜在触发因素）消退时的血管和心脏自主神经特征。
