Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
Department of Public Health, Jiangsu Health Vocational College, Nanjing, 210000, China.
Epigenomics. 2024;16(10):753-773. doi: 10.2217/epi-2024-0002. Epub 2024 Apr 19.
Cervical cancer (CC) remains one of the most common malignancies among women worldwide, posing a serious threat to women's health. N6-methyladenosine (mA) modification, as the most abundant type of RNA methylation modification, and has been found to play a crucial role in various cancers. Current research suggests a close association between RNA mA modification and the occurrence and progression of CC, encompassing disruptions in mA levels and its regulatory machinery. This review summarizes the current status of mA modification research in CC, explores the mechanisms underlying mA levels and regulators (methyltransferases, demethylases, reader proteins) in CC and examines the application of small-molecule inhibitors of mA regulators in disease treatment. The findings provide new insights into the future treatment of CC.
宫颈癌（CC）仍然是全球女性中最常见的恶性肿瘤之一，严重威胁着女性的健康。N6-甲基腺苷（mA）修饰作为最丰富的 RNA 甲基化修饰类型之一，已被发现在各种癌症中发挥关键作用。目前的研究表明，RNA mA 修饰与 CC 的发生和进展密切相关，包括 mA 水平及其调控机制的破坏。本综述总结了 mA 修饰在 CC 中的研究现状，探讨了 CC 中 mA 水平及其调控因子（甲基转移酶、去甲基酶、读码蛋白）的机制，并研究了 mA 调控因子的小分子抑制剂在疾病治疗中的应用。这些发现为 CC 的未来治疗提供了新的思路。
