Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Department of Geriatrics and Orthopedics, UniversitÀ Cattolica del Sacro Cuore, Rome, Italy.
Clin Hemorheol Microcirc. 2024;87(4):465-480. doi: 10.3233/CH-242134.
The purpose of this study was to investigate the effects of 6 weeks of resistance training (RT) combined with aerobic training (AT) and Tirzepatide supplementation on lipid profiles, insulin resistance, anthropometric characteristics and physical fitness in prediabetic obese soldiers.
61 obese men were randomly divided into six groups: Placebo; Tirzepatide 5 mg (T5); Tirzepatide 2.5 mg (T2.5); Hypertrophy, Strength, Power-Circuit Training+Placebo (Ex+P); Hypertrophy, Strength, Power-Circuit Training+Tirzepatide 5 mg (Ex+T5); Hypertrophy, Strength, Power-Circuit Training+Tirzepatide 2.5 mg (Ex+T2.5). All training groups performed aerobic training (AT) after resistance training. Subjects trained for six weeks, three sessions per week. Before and after the intervention period, the participants were evaluated for anthropometric measures, body composition [body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and fat mass (FM)], cardiorespiratory fitness (VO2max), and muscle strength (chest press 1RM and leg press 1RM). Blood biochemistry evaluations included triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), insulin level and insulin resistance (HOMA-IR). To evaluate the differences between the groups, ANCOVA statistical method was used along with Bonferroni's post hoc test, and the significance level was P < 0.05.
Body weight, BMI, WC, FM, FBG, LDL-C, TC, TG and HOMA-IR were significantly decreased in Ex+P, Ex+T5 and Ex+T2.5 groups compared to Placebo, T5 and T2.5 groups. WHR significantly decreased in Ex+P, Ex+T5 and Ex+T2.5 groups compared to Placebo group. HDL-C, chest press and leg press significantly increased in Ex+P, Ex+T5 and Ex+T2.5 groups compared to Placebo, T5 and T2.5 groups. VO2max significantly increased and insulin significantly decreased in Ex+P group compared to Placebo, T5 and T2.5 groups. FM, FBG and TG were significantly decreased in both the T2.5 and T5 groups compared to Placebo group. HOMA-IR, LDL-C and TC significantly decreased in the T5 group compared to Placebo group. Also, leg press significantly increased in Ex+P group compared to all other groups.
Performing six weeks of combined resistance and aerobic training in the form of RT+AT alone is more effective than the simultaneous use of Tirzepatide on cardiorespiratory fitness, strength, and modulating insulin levels. Taking Tirzepatide in doses of 5 mg and 2.5 mg in combination with exercise training did not have a significant advantage over exercise training alone. Finally, taking Tirzepatide in doses of 5 mg or 2.5 mg in combination with exercise training is not significantly superior to each other.
本研究旨在探讨 6 周抗阻训练（RT）联合有氧运动（AT）和 Tirzepatide 补充对肥胖、糖尿病前期士兵脂代谢谱、胰岛素抵抗、人体测量特征和身体适应能力的影响。
61 名肥胖男性被随机分为六组：安慰剂组；Tirzepatide 5mg（T5）组；Tirzepatide 2.5mg（T2.5）组；肥大、力量、功率循环训练+安慰剂（Ex+P）组；肥大、力量、功率循环训练+Tirzepatide 5mg（Ex+T5）组；肥大、力量、功率循环训练+Tirzepatide 2.5mg（Ex+T2.5）组。所有训练组在抗阻训练后均进行有氧运动（AT）。受试者每周进行 3 次，持续 6 周。干预前后，对参与者进行人体测量指标、身体成分[体重、体重指数（BMI）、腰围（WC）、腰臀比（WHR）和脂肪量（FM）]、心肺适能（VO2max）和肌肉力量（卧推 1RM 和腿推 1RM）评估。血液生化评估包括甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、胰岛素水平和胰岛素抵抗（HOMA-IR）。为了评估组间差异，使用协方差分析（ANCOVA）统计方法结合 Bonferroni 事后检验，显著性水平为 P<0.05。
与安慰剂、T5 和 T2.5 组相比，Ex+P、Ex+T5 和 Ex+T2.5 组的体重、BMI、WC、FM、FBG、LDL-C、TC、TG 和 HOMA-IR 显著降低。与安慰剂组相比，Ex+P、Ex+T5 和 Ex+T2.5 组的 WHR 显著降低。与安慰剂、T5 和 T2.5 组相比，Ex+P、Ex+T5 和 Ex+T2.5 组的 HDL-C、卧推和腿推显著增加。与安慰剂、T5 和 T2.5 组相比，Ex+P 组的 VO2max 显著增加，胰岛素显著降低。与安慰剂组相比，T2.5 和 T5 组的 FM、FBG 和 TG 显著降低。与安慰剂组相比，T5 组的 HOMA-IR、LDL-C 和 TC 显著降低。此外，与其他所有组相比，Ex+P 组的腿推显著增加。
单独进行 6 周的抗阻和有氧运动（RT+AT）训练比同时使用 Tirzepatide 更能有效提高心肺适能、力量和调节胰岛素水平。以 5mg 和 2.5mg 的剂量联合运动训练服用 Tirzepatide 并不比单独运动训练更有优势。最后，以 5mg 和 2.5mg 的剂量联合运动训练服用 Tirzepatide 彼此之间也没有显著优势。
