Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Medicine (Baltimore). 2024 Apr 19;103(16):e37699. doi: 10.1097/MD.0000000000037699.
Malignant hyperthermia (MH) is a rare yet serious medical complication that typically arises following general anesthesia or the administration of specific anesthetics. Due to the infrequency of MH, anesthesiologists often lack sufficient expertise in identifying and managing it, leading to misdiagnosis and inappropriate treatment. There is an urgent need to enhance the diagnosis and management of MH through the utilization of relevant tools.
In this case, a 52-year-old woman underwent radical cervical cancer surgery under general anesthesia, with no family or significant medical history. She experienced a gradual increase in end-tidal carbon dioxide (ETCO2) to a maximum of 75 mm Hg and a rise in body temperature from 36.5 to 37.5 °C in a very short period, as well as a blood gas analysis showing a pH of 7.217.
The anesthesiologist immediately used The WeChat applet-based National Remote Emergency System for Malignant Hyperthermia (MH-NRES), and the score was 40, which indicated that the patient was very likely to have MH.
We immediately discontinued sevoflurane and switched total intravenous anesthesia to maintain general anesthesia, with a rapid intravenous infusion of dantrolene sodium.
The ETCO2 and the temperature quickly dropped to normal, followed by successful completion of the surgery, and the patient was discharged 8 days after surgery.
The experience can provide a basis use of MH-NRES and improve the ability of anesthesiologists to deal with intraoperative MH as well as increase the survival probability of patients.
恶性高热(MH)是一种罕见但严重的医学并发症,通常在全身麻醉或特定麻醉剂给药后出现。由于 MH 的罕见性,麻醉师通常在识别和管理方面缺乏足够的专业知识,导致误诊和不当治疗。迫切需要通过使用相关工具来提高 MH 的诊断和管理水平。
本例为 52 岁女性,在全身麻醉下接受根治性宫颈癌手术,无家族或重大病史。她的呼气末二氧化碳(ETCO2)逐渐升高至最高 75mmHg,体温在很短的时间内从 36.5°C 上升至 37.5°C,血气分析显示 pH 值为 7.217。
麻醉师立即使用基于微信小程序的全国恶性高热远程应急系统(MH-NRES),得分为 40,提示患者极有可能患有 MH。
我们立即停止使用七氟醚,并切换为全凭静脉麻醉以维持全身麻醉,快速静脉输注丹曲林钠。
ETCO2 和体温迅速降至正常,随后手术成功完成,患者在手术后 8 天出院。
该经验可为 MH-NRES 的应用提供依据,并提高麻醉师在术中处理 MH 以及提高患者生存率方面的能力。