Human DNA polymerase θ does not harbor intrinsic nuclease activity.
作者信息
Carvajal-Maldonado Denisse, Zahn Karl, Jensen Ryan, Wood Richard D, Doublié Sylvie
机构信息
Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Center, Houston, TX, USA.
Repare Therapeutics, 7210 rue Frederick-Banting bureau 100, Saint-Laurent, QC H4S 2A1, Canada.
出版信息
Mol Cell. 2024 Apr 18;84(8):1394-1395. doi: 10.1016/j.molcel.2024.03.009.
Abstract
摘要
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本文引用的文献
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Stepwise requirements for polymerases δ and θ in theta-mediated end joining.聚合酶 δ 和 θ 在θ介导的末端连接中的逐步要求。
Nature. 2023 Nov;623(7988):836-841. doi: 10.1038/s41586-023-06729-7. Epub 2023 Nov 15.
2
Genome Protection by DNA Polymerase θ.DNA 聚合酶θ对基因组的保护作用。
Annu Rev Genet. 2022 Nov 30;56:207-228. doi: 10.1146/annurev-genet-072920-041046. Epub 2022 Aug 26.
3
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Cell. 1993 Feb 12;72(3):459-66. doi: 10.1016/0092-8674(93)90121-6.
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Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation.四膜虫端粒酶催化核酸裂解和非连续延伸。
Genes Dev. 1993 Jul;7(7B):1364-76. doi: 10.1101/gad.7.7b.1364.
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Most compact hairpin-turn structure exerted by a short DNA fragment, d(GCGAAGC) in solution: an extraordinarily stable structure resistant to nucleases and heat.溶液中短DNA片段d(GCGAAGC)形成的最紧密发夹结构：一种对核酸酶和热具有高度稳定性的结构。
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Extraordinarily stable mini-hairpins: electrophoretical and thermal properties of the various sequence variants of d(GCGAAAGC) and their effect on DNA sequencing.极其稳定的小发夹结构：d(GCGAAAGC)不同序列变体的电泳和热性质及其对DNA测序的影响
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