Gollman H M, Rudy T A
Res Commun Chem Pathol Pharmacol. 1985 Aug;49(2):305-8.
Using bilateral injection into the anterior hypothalamic/preoptic region of the conscious, indomethacin pretreated cat as an assay system, the pyrogenic activity of two thromboxane A2-mimetics (SQ26655 and U46619) and thromboxane B2 was assessed. PGE2 was used as a reference pyrogenic agent. Thromboxane B2 and both of the thromboxane A2-mimetics were at least 5263 times less potent than PGE2. The results do not support the putative role of thromboxanes as mediators of fever.
使用双侧注射法，将其注入到经消炎痛预处理的清醒猫的下丘脑前部/视前区，以此作为一种测定系统，评估了两种血栓素A2模拟物（SQ26655和U46619）和血栓素B2的致热活性。前列腺素E2用作参考致热剂。血栓素B2以及两种血栓素A2模拟物的效力比前列腺素E2至少低5263倍。这些结果不支持血栓素作为发热介质的假定作用。
