豚鼠灌注肺中血栓素B2积聚和代谢的选择性抑制
Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung.
作者信息
Hoult J R, Robinson C
出版信息
Br J Pharmacol. 1983 Jan;78(1):85-8. doi: 10.1111/j.1476-5381.1983.tb09366.x.
Abstract
1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F2 alpha under similar conditions. 3 The pulmonary disposition of thromboxane B2, which occurs by uptake into pulmonary cells or binding to a specific macromolecular component, is mediated by a mechanism distinct from that handling prostaglandin F2 alpha. The possible relevance of these findings to the pulmonary disposition of thromboxane A2 is discussed.
摘要
- U46619是一种前列腺素H2内过氧化物类似物和血栓素A2激动剂，它能剂量依赖性地抑制豚鼠离体灌注肺中血栓素B2的蓄积和代谢。在相似剂量下，前列腺素E1、E2、F1α、F2α、I2、5,6 -反式 - PGE2和8 -异 - PGE1均无此作用。2. 在相似条件下，U46619不影响前列腺素F2α的蓄积和代谢。3. 血栓素B2在肺中的处置是通过被肺细胞摄取或与特定大分子成分结合而发生的，其介导机制与处理前列腺素F2α的机制不同。文中讨论了这些发现与血栓素A2在肺中处置的可能相关性。
相似文献
1
Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung.豚鼠灌注肺中血栓素B2积聚和代谢的选择性抑制
Br J Pharmacol. 1983 Jan;78(1):85-8. doi: 10.1111/j.1476-5381.1983.tb09366.x.
2
Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung.
Biochim Biophys Acta. 1983 Nov 29;754(2):190-200. doi: 10.1016/0005-2760(83)90161-3.
3
Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha.
Biochim Biophys Acta. 1982 Aug 18;712(2):315-25. doi: 10.1016/0005-2760(82)90349-6.
4
Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung.血管活性肠肽对豚鼠肺中抗原诱导的支气管收缩和血栓素释放的影响。
Br J Pharmacol. 1993 May;109(1):243-50. doi: 10.1111/j.1476-5381.1993.tb13560.x.
5
A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats.豚鼠和大鼠体内前列腺素H2/血栓素A2途径参与血管内血小板聚集的比较研究。
Br J Pharmacol. 1985 Feb;84(2):425-30. doi: 10.1111/j.1476-5381.1985.tb12926.x.
6
7
The use of immobilized ligands and [125I]protein a for immunoassays of thromboxane B2, prostaglandin D2, 13,14-dihydro-prostaglandin E2, 5,6-dihydro-prostaglandin I2, 6-keto-prostaglandin F1 alpha, 15-hydroxy-9 alpha, 11 alpha(epoxymethano)prosta-5,13-dienoic acid and 15-hydroxy-11 alpha,9 alpha(epoxymethano)prosta-5,13-dienoic acid.
Prostaglandins Med. 1979 Mar;2(3):177-89. doi: 10.1016/0161-4630(79)90035-1.
8
Does thromboxane mediate the indirect contractile action of leukotriene D4 in guinea-pig isolated lung parenchyma under equilibrium conditions?在平衡条件下，血栓素是否介导白三烯D4在豚鼠离体肺实质中的间接收缩作用？
Can J Physiol Pharmacol. 1987 Jul;65(7):1467-77. doi: 10.1139/y87-230.
9
Assessment of the pyrogenic potency of the thromboxane A2-mimetics, SQ26655 and U46619, and thromboxane B2 by intrapreoptic injection in the cat.通过向猫的视前区内注射来评估血栓素A2模拟物SQ26655和U46619以及血栓素B2的致热效力。
Res Commun Chem Pathol Pharmacol. 1985 Aug;49(2):305-8.
10
Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM13,505 and AH23848.人手部静脉中介导收缩的前列腺素受体的特性：血栓素受体拮抗剂BM13,505和AH23848的作用
Acta Physiol Scand. 1991 Jan;141(1):79-86. doi: 10.1111/j.1748-1716.1991.tb09047.x.
引用本文的文献
1
Proceedings of the British Pharmacological Society, University of Cambridge, 6th-8th April, 1983. Abstracts.《英国药理学会会刊》，剑桥大学，1983年4月6日至8日。摘要
Br J Pharmacol. 1983 Jun;79 Suppl(Suppl):188P-425P.
本文引用的文献
1
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.前列腺素H2类似物U-46619与前列腺素H2及血栓素A2对某些离体平滑肌制剂作用的比较。
Br J Pharmacol. 1981 Jul;73(3):773-8. doi: 10.1111/j.1476-5381.1981.tb16814.x.
2
Inactivation of prostaglandins in the perfused rat lung.灌注大鼠肺中前列腺素的失活
Biochem Pharmacol. 1982 Mar 1;31(5):633-8. doi: 10.1016/0006-2952(82)90442-7.
3
Present concepts on the mechanisms of platelet aggregation.当前关于血小板聚集机制的概念。
Biochem Pharmacol. 1981 Feb 15;30(4):263-71. doi: 10.1016/0006-2952(81)90052-6.
4
Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha.
Biochim Biophys Acta. 1982 Aug 18;712(2):315-25. doi: 10.1016/0005-2760(82)90349-6.
5
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.血栓素：一类从前列腺素内过氧化物衍生而来的新型生物活性化合物。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):2994-8. doi: 10.1073/pnas.72.8.2994.
6
Prostaglandin removal and metabolism by isolated perfused rat lung.前列腺素在离体灌注大鼠肺中的清除与代谢
Prostaglandins. 1976 Apr;11(4):645-77. doi: 10.1016/0090-6980(76)90067-8.
7
Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung.豚鼠肺免疫激发后新型前列腺素和血栓素的释放。
Nature. 1976 Aug 19;262(5570):699-702. doi: 10.1038/262699a0.
8
Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins.
Prostaglandins. 1977 Jul;14(1):51-60. doi: 10.1016/0090-6980(77)90156-3.
9
Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay.通过放射免疫测定法测量过敏反应期间15-酮-13,14-二氢血栓素B2和前列腺素D2的释放情况。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):247-52. doi: 10.1007/BF00498818.
10
PGA1 and PGF2 alpha metabolism by pig pulmonary endothelium, smooth muscle, and fibroblasts.
J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):211-6. doi: 10.1152/jappl.1979.46.2.211.
Zotero 插件