Morio I
Arch Oral Biol. 1985;30(7):557-61. doi: 10.1016/0003-9969(85)90057-3.
Cervical loop tissues of the mandibular first molar germs were dissected from 18-day mouse embryos and recombined with the isochronal dental papilla mesenchyme. The recombinants were transplanted under the kidney capsule of syngeneic male mice. Five days later, proliferation of epithelial and mesenchymal cells was observed. At the junctional region between the internal dental epithelium and the dental papilla mesenchyme, extracellular organic matrix was deposited. By 10 days after, transplantation, the formation of dentine and enamel was initiated. Twenty days after transplantation, the recombinant developed into an almost intact molar tooth. The compensatory potential of the molar cervical loop, when recombined with the dental papilla mesenchyme, was indicated.
从18天龄小鼠胚胎中分离出下颌第一磨牙牙胚的颈环组织，并与同期牙乳头间充质重组。将重组体移植到同基因雄性小鼠的肾包膜下。5天后，观察到上皮细胞和间充质细胞的增殖。在内釉上皮和牙乳头间充质的交界处，细胞外有机基质开始沉积。移植后10天，开始形成牙本质和釉质。移植20天后，重组体发育成一颗几乎完整的磨牙。这表明了磨牙颈环与牙乳头间充质重组时的代偿潜力。
