Hu Chengchen, Francisco Jamie, Del Re Dominic P, Sadoshima Junichi
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School.
Circ J. 2024 Dec 25;89(1):6-15. doi: 10.1253/circj.CJ-24-0171. Epub 2024 Apr 19.
The evolutionarily conserved Hippo pathway plays a pivotal role in governing a variety of biological processes. Heart failure (HF) is a major global health problem with a significant risk of mortality. This review provides a contemporary understanding of the Hippo pathway in regulating different cell types during HF. Through a systematic analysis of each component's regulatory mechanisms within the Hippo pathway, we elucidate their specific effects on cardiomyocytes, fibroblasts, endothelial cells, and macrophages in response to various cardiac injuries. Insights gleaned from both in vitro and in vivo studies highlight the therapeutic promise of targeting the Hippo pathway to address cardiovascular diseases, particularly HF.
进化上保守的Hippo信号通路在调控多种生物学过程中起着关键作用。心力衰竭（HF）是一个重大的全球健康问题，具有很高的死亡风险。本综述提供了对Hippo信号通路在HF期间调节不同细胞类型的当代理解。通过对Hippo信号通路中每个组件的调节机制进行系统分析，我们阐明了它们在应对各种心脏损伤时对心肌细胞、成纤维细胞、内皮细胞和巨噬细胞的具体影响。从体外和体内研究中获得的见解突出了靶向Hippo信号通路治疗心血管疾病，特别是HF的前景。
