Banerjee Shilpita, Ghosh Pintu, Karak Anirban, Banik Dipanjan, Mahapatra Ajit Kumar
Molecular Sensor and Supramolecular Chemistry Laboratory, Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, 711 103, India.
Anal Methods. 2025 Jan 16;17(3):432-439. doi: 10.1039/d4ay00451e.
Nerve agents are among the most deadly and lethal chemical warfare agents (CWAs). Rapid identification is crucial for specialized individuals to take action against dangerous drugs. This paper describes the synthesis and characterisation of a probe (MNFZ) based on the methoxy naphthalene-furoic hydrazide group. The probe rapidly (100 s) detects and quantifies the nerve-agent simulant diethyl chlorophosphate (DCP) in both solution and vapor phases. This sensor uses a new recognition center, furoic hydrazide, where the nitrogen atom of the imine group (CN) attacks the electrophilic core phosphorus atom of DCP, followed by the hydrolysis of the imine group in the acetonitrile (ACN) solution to produce the corresponding aldehyde MNPA. The development of ICT character resulted in a distinct red-shifted ratiometric fluorescence response to DCP, with a very low limit of detection (12.2 nM). The probe is an efficient chemosensor due to its high selectivity over other organophosphorus compounds as well as its chemical stability across a wide pH range. DFT calculations, H NMR and HRMS were performed to finalize the sensing mechanism. Lastly, the as-designed sensor was successfully used to build a highly sensitive portable kit in test strips and a cotton biopolymer for simple and safe real-time monitoring of DCP.
神经毒剂是最致命的化学战剂之一。快速识别对于专业人员针对危险药物采取行动至关重要。本文描述了一种基于甲氧基萘 - 呋喃甲酰肼基团的探针（MNFZ）的合成与表征。该探针能在溶液和气相中快速（100秒）检测并定量神经毒剂模拟物氯磷酸二乙酯（DCP）。这种传感器使用了一个新的识别中心——呋喃甲酰肼，其中亚胺基团（CN）的氮原子攻击DCP的亲电核心磷原子，随后亚胺基团在乙腈（ACN）溶液中水解生成相应的醛MNPA。ICT特性的发展导致对DCP产生明显的红移比率荧光响应，检测限极低（12.2 nM）。该探针是一种高效的化学传感器，因为它对其他有机磷化合物具有高选择性，并且在很宽的pH范围内具有化学稳定性。进行了DFT计算、1H NMR和HRMS以确定传感机制。最后，所设计的传感器成功用于构建测试条形式的高灵敏度便携式试剂盒以及用于简单安全实时监测DCP的棉生物聚合物。
