School of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China.
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, 530006, China.
Anal Methods. 2024 Jan 25;16(4):515-523. doi: 10.1039/d3ay02091f.
Nerve agents are the most toxic chemical warfare agents that pose severe threat to human health and public security. In this work, we developed a novel fluorescent probe NZNN based on naphthylimide and -phenylenediamine to detect nerve agent mimic diethylchlorophosphonate (DCP). DCP underwent a specific nucleophilic reaction with the -phenylenediamine group of NZNN to produce a significant fluorescence turn-on response with high selectivity, exceptional linearity, bright fluorescence, rapid response (<6 s) and a low detection limit (30.1 nM). Furthermore, a portable sensing device was fabricated for real-time detection of DCP vapor with excellent performance. This portable and sensitive device is favorable for monitoring environmental pollution and defense against chemical warfare agents.
神经毒剂是毒性最强的化学战剂，对人类健康和公共安全构成严重威胁。在这项工作中，我们开发了一种基于萘酰亚胺和 -苯二胺的新型荧光探针 NZNN，用于检测神经毒剂模拟物二乙基膦酸氯（DCP）。DCP 与 NZNN 的 -苯二胺基团发生特异性亲核反应，产生高选择性、优异线性、明亮荧光、快速响应（<6 s）和低检测限（30.1 nM）的显著荧光开启响应。此外，还制备了一种用于实时检测 DCP 蒸气的便携式传感装置，具有优异的性能。这种便携式和灵敏的装置有利于监测环境污染和防御化学战剂。
