Marmo E
Res Commun Chem Pathol Pharmacol. 1979 Aug;25(2):195-204.
The study was designed to investigate the effect of PGF2 alpha on the arterial, cardiac and venous system and the respiration of dogs. PGF2 alpha was administered in single, graded doses as well as by i.v. perfusion. In addition, PGF2 alpha was given intra-arterially into the common carotid artery, by inhalation and by infiltration into the barosensitive zone of the carotid sinus. The interaction by drugs acting on ganglia, the catecholamine stores and the muscarinic, histaminergic, serotonergic, adrenergic and purinergic junctions, and by drugs with depressive effects at the prostaglandin receptors, also were studied. We have shown that PGF2 alpha exhibits direct, reflexes and modulator effects.
本研究旨在探讨前列腺素F2α对犬的动脉、心脏和静脉系统以及呼吸的影响。前列腺素F2α以单次分级剂量以及静脉灌注的方式给药。此外，还通过将前列腺素F2α经颈总动脉动脉内给药、吸入给药以及浸润到颈动脉窦压力感受区给药。同时还研究了作用于神经节、儿茶酚胺储存以及毒蕈碱能、组胺能、5-羟色胺能、肾上腺素能和嘌呤能接头的药物之间的相互作用，以及对前列腺素受体有抑制作用的药物之间的相互作用。我们已经表明，前列腺素F2α具有直接、反射和调节作用。
