Zhang Yuhai, Yu Jingwen, Fan Cunxia, Wang Fei, Liu Haiwei, Chen Kaining
Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Front Endocrinol (Lausanne). 2024 Apr 5;15:1310408. doi: 10.3389/fendo.2024.1310408. eCollection 2024.
Adrenocortical carcinoma (ACC) is a rare malignancy originating in the adrenal glands, aldosterone-producing ACC, even rarer. Papillary thyroid carcinoma (PTC), by contrast, accounts for the majority of thyroid carcinomas. We herein describe the first reported case of a female with comorbidities of aldosterone-producing ACC, PTC, and Graves' Disease(GD). The patient achieved transient clinical remission following adrenalectomy. However, three months later, aldosterone-producing ACC lung metastases emerged. Subsequently, within another three-month interval, she developed thyroid eye disease(TED). The patient died roughly one year after the adrenal operation. Exome sequencing did not reveal associations between aldosterone-producing ACC, PTC, and GD, and the underlying concurrence mechanism has yet to be elucidated. Further research of similar cases are needed to confirm potential links between the three pathologies.
肾上腺皮质癌（ACC）是一种起源于肾上腺的罕见恶性肿瘤，产生醛固酮的ACC则更为罕见。相比之下，甲状腺乳头状癌（PTC）占甲状腺癌的大多数。我们在此描述首例报告的患有产生醛固酮的ACC、PTC和格雷夫斯病（GD）合并症的女性病例。患者在肾上腺切除术后实现了短暂的临床缓解。然而，三个月后，出现了产生醛固酮的ACC肺转移。随后，在又一个三个月的间隔内，她患上了甲状腺眼病（TED）。患者在肾上腺手术后约一年死亡。外显子组测序未发现产生醛固酮的ACC、PTC和GD之间的关联，其潜在的并发机制尚待阐明。需要对类似病例进行进一步研究，以确认这三种病理之间的潜在联系。
