Sadeghi Najmeh, Mohebali Mehdi, Kakooei Zahra, Roustazadeh Abazar, Mir Hamed, Abdoli Amir, Solhjoo Kavous, Shabani Manoochehr, Shadmand Enayatollah, Taghipour Ali
Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Parasite Epidemiol Control. 2024 Apr 16;25:e00349. doi: 10.1016/j.parepi.2024.e00349. eCollection 2024 May.
Visceral leishmaniasis (VL) is a public health issue in endemic countries with poor sanitation facilities. In this study, the seroprevalence rate and associated risk factors of VL were investigated during September 2020 to February 2021 in pregnant women referred to Ostad Mottahari and Peymanieh hospitals in Jahrom county, Fars province, southern Iran.
A total of 220 serum samples of pregnant women were assessed for the presence of Anti antibodies by direct agglutination antigen (DAT). The associated risk factors were obtained using questionnaires.
The overall seroprevalence of VL in pregnant women was 12.72% (28/220). Considering the antibody titer, titer 1:1600 was detected in 23 samples, titer 1:3200 in 4 samples, and titer 1:6400 in one sample. All 5 women with titer >3200 had mild fever. As such, there was a statistically significant difference regarding the age (≥39 years old with value: 0.01).
We recommend an appropriate health education program for pregnant women and serological screening of VL before pregnancy in endemic cities. Moreover, we believed a need for more epidemiological studies for better understand the status of VL in pregnant women.
内脏利什曼病（VL）在卫生设施差的流行国家是一个公共卫生问题。在本研究中，于2020年9月至2021年2月期间，对转诊至伊朗南部法尔斯省贾赫罗姆县奥斯坦德·莫塔哈里医院和佩马尼耶医院的孕妇进行了VL血清流行率及相关危险因素的调查。
通过直接凝集抗原（DAT）对220份孕妇血清样本进行抗抗体检测。通过问卷获取相关危险因素。
孕妇中VL的总体血清流行率为12.72%（28/220）。考虑抗体滴度，在23份样本中检测到滴度为1:1600，4份样本中为1:3200，1份样本中为1:6400。所有5名滴度>3200的女性均有低热。因此，年龄方面存在统计学显著差异（≥39岁，P值：0.01）。
我们建议为孕妇开展适当的健康教育项目，并在流行城市对孕妇进行孕前VL血清学筛查。此外，我们认为需要开展更多的流行病学研究，以更好地了解孕妇中VL的状况。
