Pan Zijian, Zhou Xue'er, Cao Zhiwei, Pan Jian
（ 610041） State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Mar 20;55(2):256-262. doi: 10.12182/20240360103.
Runt-related transcription factor (RUNX1) is a transcription factor closely involved in hematopoiesis. 1 gene mutation plays an essential pathogenic role in the initiation and development of hematological tumors, especially in acute myeloid leukemia. Recent studies have shown that RUNX1 is also involved in the regulation of bone development and the pathological progression of bone-related diseases. RUNX1 promotes the differentiation of mesenchymal stem cells into chondrocytes and osteoblasts and modulates the maturation and extracellular matrix formation of chondrocytes. The expression of RUNX1 in mesenchymal stem cells, chondrocytes, and osteoblasts is of great significance for maintaining normal bone development and the mass and quality of bones. RUNX1 also inhibits the differentiation and bone resorptive activities of osteoclasts, which may be influenced by sexual dimorphism. In addition, RUNX1 deficiency contributes to the pathogenesis of osteoarthritis, delayed fracture healing, and osteoporosis, which was revealed by the RUNX1 conditional knockout modeling in mice. However, the roles of RUNX1 in regulating the hypertrophic differentiation of chondrocytes, the sexual dimorphism of activities of osteoclasts, as well as bone loss in diabetes mellitus, senescence, infection, chronic inflammation, etc, are still not fully understood. This review provides a systematic summary of the research progress concerning RUNX1 in the field of bone biology, offering new ideas for using RUNX1 as a potential target for bone related diseases, especially osteoarthritis, delayed fracture healing, and osteoporosis.
runt相关转录因子（RUNX1）是一种与造血密切相关的转录因子。1基因突变在血液系统肿瘤的发生和发展中起着至关重要的致病作用，尤其是在急性髓系白血病中。最近的研究表明，RUNX1还参与骨发育的调节以及骨相关疾病的病理进展。RUNX1促进间充质干细胞向软骨细胞和成骨细胞分化，并调节软骨细胞的成熟和细胞外基质形成。RUNX1在间充质干细胞、软骨细胞和成骨细胞中的表达对于维持正常骨发育以及骨骼的质量和数量具有重要意义。RUNX1还抑制破骨细胞的分化和骨吸收活性，这可能受性别差异影响。此外，通过小鼠RUNX1条件性敲除模型揭示，RUNX1缺乏会导致骨关节炎、骨折愈合延迟和骨质疏松症的发病机制。然而，RUNX1在调节软骨细胞肥大分化、破骨细胞活性的性别差异以及糖尿病、衰老、感染、慢性炎症等情况下的骨质流失中的作用仍未完全了解。本综述系统总结了骨生物学领域中关于RUNX1的研究进展，为将RUNX1用作骨相关疾病，尤其是骨关节炎、骨折愈合延迟和骨质疏松症的潜在靶点提供了新思路。
