Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, N13 W7, Sapporo 060-8586, Hokkaido, Japan.
Department of Vascular Biology, Faculty and Graduate School of Dental Medicine, Hokkaido University, N13 W7, Sapporo 060-8586, Hokkaido, Japan.
Int J Mol Sci. 2023 Jun 30;24(13):10912. doi: 10.3390/ijms241310912.
Bone is a highly vascularized organ that not only plays multiple roles in supporting the body and organs but also endows the microstructure, enabling distinct cell lineages to reciprocally interact. Recent studies have uncovered relevant roles of the bone vasculature in bone patterning, morphogenesis, homeostasis, and pathological bone destruction, including osteoporosis and tumor metastasis. This review provides an overview of current topics in the interactive molecular events between endothelial cells and bone cells during bone ontogeny and discusses the future direction of this research area to find novel ways to treat bone diseases.
骨骼是一种高度血管化的器官，不仅在支撑身体和器官方面发挥多种作用，而且赋予微观结构，使不同的细胞谱系能够相互作用。最近的研究揭示了骨脉管系统在骨模式形成、形态发生、动态平衡和病理性骨破坏（包括骨质疏松症和肿瘤转移）中的相关作用。本综述概述了在骨骼发生过程中内皮细胞和骨细胞之间相互作用的分子事件的当前研究课题，并讨论了该研究领域的未来方向，以寻找治疗骨骼疾病的新方法。
