Audrain-McGovern Janet, Klapec Olivia, Koita Fodie, Manikandan Divya, Stone Matthew D
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Drug Alcohol Depend Rep. 2024 Apr 9;11:100234. doi: 10.1016/j.dadr.2024.100234. eCollection 2024 Jun.
Young adults 18-24 years old have the highest prevalence of cigarillo use, exposing young adults to comparable or higher nicotine levels and many of the same toxicants as combustible cigarettes. Identifying individual and product characteristics that increase the potential for persistent use is warranted. We sought to examine the interacting effects of depression symptoms and sweet flavoring on the rewarding and reinforcing value of cigarillo use.
86 young adults (18-24 years old, 73.3 % male, 38.4 % White, 33.7 % Black, and 27.9 % Other) completed three laboratory visits assessing the subjective rewarding value (exposure paradigm), relative reinforcing value (computerized choice task), and absolute reinforcing value (ad libitum cigarillo smoking session) of sweet-flavored versus non-flavored cigarillos. Depression symptoms were measured with the 20-item Center for Epidemiologic Studies of Depression Scale and treated as a continuous variable.
General linear models with the appropriate family link tested differences in depressive symptomology for each outcome. Irrespective of flavor, greater cigarillo subjective reward was reported across increasing depressive symptomology (B=.0.03 [95%CI=0.00, 0.05], =.017). Across symptom levels, no significant differences were observed in the subjective reward and relative and absolute reinforcing values of sweet-flavored versus non-flavored cigarillos ('s >.05).
Young adults with elevated depression find cigarillos more rewarding but not more reinforcing. They are not more vulnerable than young adults with lower symptom levels to sweet cigarillo flavoring. Public health prevention campaigns and tobacco product regulations aimed at preventing the initiation and escalation of young adult cigarillo use may impact young adults broadly.
18至24岁的年轻人吸小雪茄的比例最高,这使他们接触到与可燃香烟相当或更高的尼古丁水平以及许多相同的有毒物质。确定会增加持续使用可能性的个人和产品特征很有必要。我们试图研究抑郁症状和甜味调味剂对吸小雪茄的奖赏和强化价值的交互作用。
86名年轻人(18至24岁,73.3%为男性,38.4%为白人,33.7%为黑人,27.9%为其他种族)完成了三次实验室访视,评估了甜味与无味小雪茄的主观奖赏价值(暴露范式)、相对强化价值(计算机化选择任务)和绝对强化价值(自由吸小雪茄时段)。抑郁症状用20项流行病学研究中心抑郁量表进行测量,并作为连续变量处理。
采用适当家族联系的一般线性模型检验了每种结果的抑郁症状差异。无论口味如何,随着抑郁症状的增加,报告的小雪茄主观奖赏更高(B = 0.03 [95%置信区间 = 0.00, 0.05],P = 0.017)。在各个症状水平上,甜味与无味小雪茄的主观奖赏、相对和绝对强化价值均未观察到显著差异(P > 0.05)。
抑郁程度较高的年轻人觉得吸小雪茄更有奖赏感,但强化作用并未增强。与症状水平较低的年轻人相比,他们对甜味小雪茄调味剂并不更易受影响。旨在预防年轻人吸小雪茄开始和升级的公共卫生预防运动和烟草产品监管可能会广泛影响年轻人。