Arafah Albandari A
Microbiology, Fakeeh College of Medical Sciences, Makkah, SAU.
Cureus. 2024 Mar 21;16(3):e56614. doi: 10.7759/cureus.56614. eCollection 2024 Mar.
Antibiotic resistance is a global public health concern that poses a significant threat to the effective treatment of bacterial infections. , a family of gram-negative bacteria, are associated with a wide range of infections, including urinary tract infections, bloodstream infections, and respiratory tract infections. This systematic review aimed to examine the antibiotic resistance trend among in Saudi Arabia in the period between 2003 and 2023. Five databases (PubMed, Medline, Ovid, Scopus, and Cochrane) were searched using the keywords "Resistance AND Enterobacteriaceae AND Saudi Arabia" in the title and abstract. All papers assessing the prevalence of resistance among in Saudi Arabia were included in the systematic review. Out of 97 papers that were extracted through the database search, 22 articles were considered suitable for the systematic review. The articles included 17027 isolates, out of which 7592 isolates were identified as resistant bacteria. The studies included various resistant strains, such as and , that were responsible for various clinical conditions, including urinary tract infections, blood infections, surgical site infections, and pneumonia. In addition, the review highlighted the dynamic nature of antibiotic resistance, with the identification of new resistant bacterial species and the emergence of resistance to newer antibiotic classes over the last decade. Continued surveillance, rational antibiotic use, and the development of alternative treatment options are crucial to address the evolving landscape of antibiotic resistance among bacteria in the country.
抗生素耐药性是一个全球公共卫生问题，对细菌感染的有效治疗构成重大威胁。肠杆菌科是一类革兰氏阴性菌，与多种感染有关，包括尿路感染、血流感染和呼吸道感染。本系统评价旨在研究2003年至2023年期间沙特阿拉伯肠杆菌科的抗生素耐药趋势。使用标题和摘要中的关键词“耐药性与肠杆菌科与沙特阿拉伯”检索了五个数据库（PubMed、Medline、Ovid、Scopus和Cochrane）。所有评估沙特阿拉伯肠杆菌科耐药性流行情况的论文都纳入了该系统评价。通过数据库检索提取的97篇论文中，22篇文章被认为适合进行系统评价。这些文章包括17027株肠杆菌科分离株，其中7592株分离株被鉴定为耐药菌。这些研究包括各种耐药菌株，如大肠杆菌和肺炎克雷伯菌，它们导致了各种临床病症，包括尿路感染、血液感染、手术部位感染和肺炎。此外，该评价强调了抗生素耐药性的动态性质，在过去十年中发现了新的耐药细菌种类以及对新型抗生素类别的耐药性出现。持续监测、合理使用抗生素以及开发替代治疗方案对于应对该国肠杆菌科细菌不断变化的抗生素耐药情况至关重要。
