Muthusamy Raman, Mahesh Saisri, Travasso Christy
Microbiology, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Medicine, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Cureus. 2024 Mar 21;16(3):e56632. doi: 10.7759/cureus.56632. eCollection 2024 Mar.
Introduction In general, with frequent recurrence of urinary tract infections (UTIs), long-term antibiotic therapy is stipulated at a low dose. With this type of situation and with easy access to several classes of antibiotics in tertiary health care settings, the use of such drugs results in the development of resistant bacteria in patients. is a frequent cause of UTI observed. Hence, it was proposed in the present study to assess the antimicrobial resistance status of in UTI-infected patients. Methods This study was conducted among female patients diagnosed with UTI. About 80 urine samples were collected in an aseptic condition, Under the process of culture identification 44 samples were found to be positive for UTI infection. The positive samples were plated on blood agar. Out of 44 samples, 18 samples were found to be positive, and 26 samples were negative for infection. The 18 samples were screened on MALDI-TOF for identification. Further, the samples were assessed for susceptibility to antibiotic medication within the study area. Result The study identified different strains ofand the CHB gene found in eight samples. The sample showed pink oval-round spots in the culture medium and was resistant to nitrofurantoin, cephalosporin, and cephalexin antibiotics. Hence, antimicrobial susceptibility tests are necessary for managing and treating bacterial infections. Conclusion is a common bacterium found in the vaginal region of patients, suggesting a potential infection. can be associated with UTIs in women. The results from this study conclude that is rapidly becoming multidrug-resistant, as only higher antibiotics can inhibit its growth. To effectively manage infections caused by proper diagnosis, laboratory testing, and antibiotic treatment are required.
引言 一般来说，对于反复发生的尿路感染（UTI），规定进行低剂量的长期抗生素治疗。在这种情况下，并且在三级医疗保健机构中容易获得几类抗生素，使用这些药物会导致患者体内产生耐药菌。是观察到的UTI的常见病因。因此，本研究提出评估UTI感染患者中的抗菌药物耐药状况。方法 本研究在诊断为UTI的女性患者中进行。在无菌条件下收集了约80份尿液样本，在培养鉴定过程中，发现44份样本UTI感染呈阳性。将阳性样本接种在血琼脂平板上。在44份样本中，发现18份样本呈阳性，26份样本感染呈阴性。对18份样本进行基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）筛选以进行鉴定。此外，在研究区域内评估样本对抗生素药物的敏感性。结果 该研究鉴定出不同菌株以及在8份样本中发现的CHB基因。该样本在培养基中显示粉红色椭圆形斑点，并且对呋喃妥因、头孢菌素和头孢氨苄抗生素耐药。因此，抗菌药物敏感性试验对于管理和治疗细菌感染是必要的。结论 是在患者阴道区域发现的常见细菌，提示潜在感染。可与女性UTI相关。本研究结果表明，正迅速成为多重耐药菌，因为只有更高剂量的抗生素才能抑制其生长。为了有效管理由引起的感染，需要进行正确的诊断、实验室检测和抗生素治疗。
