Perry Matthew T, Witten Andrew J, Marwan Majeed, Vortmeyer Alexander, Tailor Jignesh
Neurological Surgery, Indiana University School of Medicine, Indianapolis, USA.
Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Cureus. 2024 Mar 20;16(3):e56547. doi: 10.7759/cureus.56547. eCollection 2024 Mar.
Rhabdomyosarcoma (RMS) is a pediatric malignancy with a variable prognosis depending on tumor stage and genotype. There has been a significant improvement in survival rates over the past decades. However, aggressive variants can metastasize to locations that are difficult to treat. We report a case of prostatic alveolar rhabdomyosarcoma with metastases to the bone marrow and thoracic spine in a child. The patient was treated with a multimodal approach that included surgical resection of the epidural mass; the administration of vincristine, dactinomycin, and cyclophosphamide; and radiotherapy. Unfortunately, after six months, the patient showed disease progression and was started on secondary-line treatment. This case illustrates the difficulties in managing end-stage metastatic rhabdomyosarcoma and is the first report of prostatic rhabdomyosarcoma presenting with spinal cord compression in a child.
横纹肌肉瘤（RMS）是一种儿科恶性肿瘤，其预后因肿瘤分期和基因型而异。在过去几十年中，生存率有了显著提高。然而，侵袭性变体可转移至难以治疗的部位。我们报告了一例儿童前列腺泡状横纹肌肉瘤，伴有骨髓和胸椎转移。该患者接受了多模式治疗，包括手术切除硬膜外肿块；给予长春新碱、放线菌素D和环磷酰胺；以及放疗。不幸的是，六个月后，患者病情进展，开始接受二线治疗。该病例说明了晚期转移性横纹肌肉瘤治疗的困难，并且是儿童前列腺横纹肌肉瘤伴脊髓压迫的首例报告。
