对从……分离出的内生真菌代谢产物的化学及活性研究。 (原句中“isolated from”后面缺少具体内容)

Chemical and activity investigation on metabolites from the endophytic fungus isolated from .

作者信息

Chen Jianshu, Tao Zhaoyang, Yang Shengli

机构信息

The College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.

出版信息

Nat Prod Res. 2025 Jun;39(12):3433-3437. doi: 10.1080/14786419.2024.2337111. Epub 2024 Apr 22.

Abstract

was isolated for the first time from the leaves of (VSN-2022-03-18-001) and found to produce bioactive compounds. Seven compounds were obtained from the fermentation broth and mycelia of and identified as palmitic acid (), methyl 6-acetyl-5,7,8-trihydroxy-4-methoxy-2-naphthoate (), ergosterol (), daidzein (), oleuropein (), pedunculoside () and acteoside (). Compounds , and exhibited antioxidant activity against diphenyl picryl hydrazinyl with IC values of 58.06, 2.58 and 12.01 µg/mL, respectively. Compounds , and exhibit inhibitory activity against with MIC values of 0.78, 3.13 and 3.13 mg/mL, while compounds , , , , and exhibited inhibitory effect on with MIC values of 0.20, 0.20, 0.39, 0.63, 0.78 and 0.78 mg/mL, respectively. Furthermore, Compound effectively inhibited HepG2 cells, showing an IC of 34.03 μg/mL.

摘要

首次从(VSN - 2022 - 03 - 18 - 001)的叶片中分离出来,并发现其能产生生物活性化合物。从该菌的发酵液和菌丝体中获得了七种化合物,分别鉴定为棕榈酸()、6 - 乙酰基 - 5,7,8 - 三羟基 - 4 - 甲氧基 - 2 - 萘甲酸甲酯()、麦角甾醇()、大豆苷元()、橄榄苦苷()、悬钩子苷()和毛蕊花糖苷()。化合物、和对二苯基苦味酰基肼表现出抗氧化活性,IC值分别为58.06、2.58和12.01μg/mL。化合物、和对表现出抑制活性,MIC值分别为0.78、3.13和3.13mg/mL,而化合物、、、、和对表现出抑制作用,MIC值分别为0.20、0.20、0.39、0.63、0.78和0.78mg/mL。此外,化合物有效抑制HepG2细胞,IC为34.03μg/mL。

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