Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
Department of Endocrinology, Diabetes and Isotope Therapy, University Clinical Hospital, Wroclaw, Poland.
Endokrynol Pol. 2024;75(2):199-206. doi: 10.5603/ep.99111. Epub 2024 Apr 22.
Research on obesity, which results from excessive food consumption and sedentary lifestyle, has focused on increasing energy expenditure. Recently, muscle tissue is being investigated as an endocrine active organ, secreting molecules called myokines. Multiple studies have been performed to assess myokine levels in various disorders, including polycystic ovary syndrome (PCOS) and metabolic syndrome. Irisin and Meteorin-like protein (Metrnl) are particles which, among others, are suggested to play an important role in adipose tissue browning and improving insulin sensitivity.
The study population consisted of 31 women with PCOS and 18 healthy individuals. PCOS was diagnosed based on revised 2003 Rotterdam criteria. Multiple anthropometrical, hormonal, and biochemical parameters were assessed, including oral glucose tolerance test and body composition with dual energy X-ray absorptiometry. Serum levels of irisin and Metrnl were measured by enzyme-linked immunosorbent assay (ELISA).
There were no differences between the PCOS and control groups according to age, body mass index (BMI), waist-to-hip ratio (WHR), fasting glucose, homeostasis model assessment of insulin resistance (HOMA-IR), or body mass composition. Assessment of Metrnl and irisin concentrations revealed no significant differences between PCOS and healthy women. The irisin level was negatively correlated with BMI, body fat mass, fasting glucose, and insulin concentrations. No relationship between Metrnl level and metabolic parameters was found.
Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.
肥胖是由过度饮食和久坐不动的生活方式引起的，目前针对肥胖的研究主要集中在增加能量消耗上。最近，肌肉组织被认为是一种内分泌活跃的器官，它分泌一种叫做肌因子的分子。已经有多项研究评估了各种疾病中的肌因子水平，包括多囊卵巢综合征（PCOS）和代谢综合征。鸢尾素和 Meteorin-like protein（Metrnl）是被认为在脂肪组织褐变和改善胰岛素敏感性中起重要作用的颗粒之一。
研究人群包括 31 名患有 PCOS 的女性和 18 名健康个体。根据修订后的 2003 年鹿特丹标准诊断 PCOS。评估了多种人体测量、激素和生化参数，包括口服葡萄糖耐量试验和双能 X 射线吸收法测定的身体成分。通过酶联免疫吸附试验（ELISA）测量血清鸢尾素和 Metrnl 水平。
根据年龄、体重指数（BMI）、腰臀比（WHR）、空腹血糖、稳态模型评估的胰岛素抵抗（HOMA-IR）或体重组成，PCOS 组和对照组之间没有差异。评估 Metrnl 和鸢尾素浓度，未发现 PCOS 与健康女性之间存在显著差异。鸢尾素水平与 BMI、体脂肪量、空腹血糖和胰岛素浓度呈负相关。未发现 Metrnl 水平与代谢参数之间存在关系。
尽管鸢尾素似乎是一种很有前途的生物标志物，但不一致的研究限制了其在肥胖评估或治疗中的临床应用价值。Metrnl 水平在研究人群中不受影响，但它可能与代谢紊乱的严重程度有关。
