Cho C H, Ogle C W, Wong S H, Koo M W
Digestion. 1985;32(4):288-95. doi: 10.1159/000199250.
The effect of zinc sulphate on stomach ulceration produced by ethanol and indomethacin was examined in rats. Oral or intraperitoneal pretreatment with zinc sulphate (20 mg/kg, expressed as zinc ion) strongly prevented ethanol-, but not indomethacin-induced gastric glandular ulceration. Indomethacin given beforehand did not influence the protective action of zinc sulphate against ethanol-evoked lesions. Ethanol decreased histamine levels, whereas indomethacin reduced the prostaglandin E2 (PGE2) content in the gastric glandular mucosa. The alcohol also elevated the histamine content in gastric secretion. Zinc sulphate reversed the ethanol-induced changes in histamine levels in both mucosa and secretion, but did not modify PGE2 reduction by indomethacin. Zinc sulphate also antagonised protein leakage from the stomach following ethanol administration. It is concluded that gastric ulceration by the currently employed doses of ethanol and indomethacin is caused by different mechanisms. Zinc sulphate prevents histamine-mediated lesions produced by the alcohol, but not ulceration due to PGE2 depletion by indomethacin.
研究了硫酸锌对乙醇和吲哚美辛所致大鼠胃溃疡的影响。用硫酸锌（20mg/kg，以锌离子计）进行口服或腹腔预处理，可强烈预防乙醇诱导的胃腺溃疡，但对吲哚美辛诱导的胃腺溃疡无效。预先给予吲哚美辛并不影响硫酸锌对乙醇诱发损伤的保护作用。乙醇可降低组胺水平，而吲哚美辛可降低胃腺黏膜中前列腺素E2（PGE2）的含量。乙醇还可提高胃分泌液中的组胺含量。硫酸锌可逆转乙醇诱导的黏膜和分泌液中组胺水平的变化，但不能改变吲哚美辛所致的PGE2降低。硫酸锌还可拮抗乙醇给药后胃内蛋白质渗漏。得出结论：目前所用剂量的乙醇和吲哚美辛所致胃溃疡是由不同机制引起的。硫酸锌可预防乙醇介导的损伤，但不能预防吲哚美辛所致PGE2耗竭引起的溃疡。
