Arakawa T, Satoh H, Nakamura A, Nebiki H, Fukuda T, Sakuma H, Nakamura H, Ishikawa M, Seiki M, Kobayashi K
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Dig Dis Sci. 1990 May;35(5):559-66. doi: 10.1007/BF01540402.
The effects of zinc L-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosa in vivo and in vitro. When given either intragastrically or intraperitoneally, zinc L-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zinc L-carnosine was not inhibited by indomethacin. Histological assessment showed that zinc L-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl prostaglandin E2. Zinc L-carnosine (10(-6) or 10(-5) M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosa in vitro; this effect was not inhibited by indomethacin. The results suggested that zinc L-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.
在大鼠胃黏膜的体内和体外实验中，评估了L-肌肽锌对乙醇诱导损伤的影响以及这些影响与内源性前列腺素E2的相关性。当通过胃内或腹腔内给予L-肌肽锌（10或30mg/kg）时，可预防乙醇引起的胃黏膜明显可见损伤，且不影响黏膜前列腺素E2水平。L-肌肽锌的这种保护作用不受吲哚美辛的抑制。组织学评估显示，L-肌肽锌抑制了深层黏膜坏死，16,16-二甲基前列腺素E2也有同样作用。L-肌肽锌（10(-6)或10(-5)M）在体外抑制了乙醇对从大鼠胃黏膜分离的胃细胞造成的损伤；该作用不受吲哚美辛的抑制。结果表明，L-肌肽锌可保护胃黏膜并增强细胞对乙醇的抗性，且无需内源性前列腺素的介导。
