L-肌肽锌对大鼠乙醇所致胃黏膜及细胞损伤的影响。与内源性前列腺素E2的相关性。
Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2.
作者信息
Arakawa T, Satoh H, Nakamura A, Nebiki H, Fukuda T, Sakuma H, Nakamura H, Ishikawa M, Seiki M, Kobayashi K
机构信息
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
出版信息
Dig Dis Sci. 1990 May;35(5):559-66. doi: 10.1007/BF01540402.
The effects of zinc L-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosa in vivo and in vitro. When given either intragastrically or intraperitoneally, zinc L-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zinc L-carnosine was not inhibited by indomethacin. Histological assessment showed that zinc L-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl prostaglandin E2. Zinc L-carnosine (10(-6) or 10(-5) M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosa in vitro; this effect was not inhibited by indomethacin. The results suggested that zinc L-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.
在大鼠胃黏膜的体内和体外实验中，评估了L-肌肽锌对乙醇诱导损伤的影响以及这些影响与内源性前列腺素E2的相关性。当通过胃内或腹腔内给予L-肌肽锌（10或30mg/kg）时，可预防乙醇引起的胃黏膜明显可见损伤，且不影响黏膜前列腺素E2水平。L-肌肽锌的这种保护作用不受吲哚美辛的抑制。组织学评估显示，L-肌肽锌抑制了深层黏膜坏死，16,16-二甲基前列腺素E2也有同样作用。L-肌肽锌（10(-6)或10(-5)M）在体外抑制了乙醇对从大鼠胃黏膜分离的胃细胞造成的损伤；该作用不受吲哚美辛的抑制。结果表明，L-肌肽锌可保护胃黏膜并增强细胞对乙醇的抗性，且无需内源性前列腺素的介导。
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