硫酸锌对利血平诱导的大鼠溃疡及其他胃部影响的保护作用。
Protection by zinc sulphate against reserpine-induced ulceration and other gastric effects in the rat.
作者信息
Ogle C W, Cho C H
出版信息
Pharmacology. 1978;17(5):254-61. doi: 10.1159/000136864.
The effects of intraperitoneal pretreatment, 48 h beforehand, with zinc sulphate (22, 44 or 88 mg/kg) were studied on gastric ulceration, gastric secretion and changes in stomach wall mast cell counts induced after 4 h by reserpine (5 mg/kg) given intraperitoneally to intact (unoperated for pylorus occlusion) or pylorus-occluded rats. Zinc sulphate dose-dependently antagonised the gastric actions of reserpine by preventing ulceration in the ruminal and glandular segments of the stomach, reducing acid secretion, and inhibiting mast cell degranulation which occurred mainly in the glandular mucosal layer. The relationship between these findings and the action of zinc on gastric mast cell is discussed.
研究了在完整（未进行幽门结扎手术）或幽门结扎的大鼠腹腔注射利血平（5mg/kg）4小时前48小时腹腔预处理硫酸锌（22、44或88mg/kg）对胃溃疡形成、胃分泌以及胃壁肥大细胞计数变化的影响。硫酸锌通过预防胃瘤胃段和腺胃段溃疡、减少胃酸分泌以及抑制主要发生在腺胃黏膜层的肥大细胞脱颗粒，剂量依赖性地拮抗利血平的胃作用。讨论了这些发现与锌对胃肥大细胞作用之间的关系。
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