Department of Computing, University of Turku, Faculty of Technology, Vesilinnantie 5, Turku, 20500, Finland.
Department of Internal Medicine, University of Turku, Kiinamyllynkatu 4-8, Turku, 20521, Finland.
Adv Sci (Weinh). 2024 Jun;11(24):e2307718. doi: 10.1002/advs.202307718. Epub 2024 Apr 22.
Results from two independent clinical validation studies for measuring hemodynamics at the patient's bedside using a compact finger probe are reported. Technology comprises a barometric pressure sensor, and in one implementation, additionally, an optical sensor for photoplethysmography (PPG) is developed, which can be used to measure blood pressure and analyze rhythm, including the continuous detection of atrial fibrillation. The capabilities of the technology are shown in several form factors, including a miniaturized version resembling a common pulse oximeter to which the technology could be integrated in. Several main results are presented: i) the miniature finger probe meets the accuracy requirements of non-invasive blood pressure instrument validation standard, ii) atrial fibrillation can be detected during the blood pressure measurement and in a continuous recording, iii) a unique comparison between optical and pressure sensing mechanisms is provided, which shows that the origin of both modalities can be explained using a pressure-volume model and that recordings are close to identical between the sensors. The benefits and limitations of both modalities in hemodynamic monitoring are further discussed.
本文报告了使用紧凑的手指探头在患者床边测量血液动力学的两项独立临床验证研究的结果。该技术包括一个气压传感器，在一种实现方式中，还开发了一个用于光体积描记法（PPG）的光学传感器，可用于测量血压和分析节律，包括连续检测心房颤动。该技术的功能在几种外形因素中得到了展示，包括一种类似于常见脉搏血氧仪的微型版本，该技术可以集成到其中。呈现了几个主要结果：i）微型手指探头符合非侵入性血压仪器验证标准的准确性要求，ii）可以在血压测量和连续记录期间检测到心房颤动，iii）提供了光学和压力感应机制之间的独特比较，表明两种模式的起源都可以用压力-容积模型来解释，并且传感器之间的记录非常接近。进一步讨论了两种模式在血液动力学监测中的优势和局限性。
