Department of Computing, University of Turku, Vesilinnantie 5, Turku, 20500, Finland.
Adv Sci (Weinh). 2024 Jun;11(24):e2310022. doi: 10.1002/advs.202310022. Epub 2024 Apr 22.
Minimally invasive and non-invasive hemodynamic monitoring technologies have recently gained more attention, driven by technological advances and the inherent risk of complications in invasive techniques. In this article, an experimental non-invasive system is presented that effectively combines the capabilities of spectrometry, photoplethysmography (PPG), and arterial pressure measurement. Both time- and wavelength-resolved optical signals from the fingertip are measured under external pressure, which gradually increased above the level of systolic blood pressure. The optical channels measured at 434-731 nm divided into three groups separated by a group of channels with wavelengths approximately between 590 and 630 nm. This group of channels, labeled transition band, is characterized by abrupt changes resulting from a decrease in the absorption coefficient of whole blood. External pressure levels of maximum pulsation showed that shorter wavelengths (<590 nm) probe superficial low-pressure blood vessels, whereas longer wavelengths (>630 nm) probe high-pressure arteries. The results on perfusion indices and DC component level changes showed clear differences between the optical channels, further highlighting the importance of wavelength selection in optical hemodynamic monitoring systems. Altogether, the results demonstrated that the integrated system presented has the potential to extract new hemodynamic information simultaneously from macrocirculation to microcirculation.
近年来,由于技术进步和侵入性技术固有的并发症风险,微创和非侵入性血流动力学监测技术受到了更多关注。本文提出了一种有效的实验性非侵入性系统,它有效地结合了光谱、光体积描记术(PPG)和动脉血压测量的功能。在外部压力下测量指尖的时间和波长分辨光信号,该外部压力逐渐增加到高于收缩压水平。在 434-731nm 范围内测量的光通道分为三组,每组通道之间的波长约为 590nm 到 630nm。该组通道标记为过渡带,其特征是由于全血吸收系数降低而导致的突然变化。最大脉动的外部压力水平表明,较短的波长(<590nm)探测浅层低压血管,而较长的波长(>630nm)探测高压动脉。灌注指数和 DC 分量电平变化的结果在光通道之间显示出明显的差异,进一步强调了在光学血流动力学监测系统中选择波长的重要性。总之,结果表明,所提出的集成系统有可能同时从宏观循环到微循环中提取新的血流动力学信息。