Pereira Ana, Corvalan Camila, Merino Paulina M, Leiva Valeria, Mericq Verónica
Institute of Nutrition and Food Technology, Faculty of Medicine, University of Chile, Santiago, Chile.
Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago, Chile.
J Pediatr Adolesc Gynecol. 2019 Dec;32(6):579-583. doi: 10.1016/j.jpag.2019.08.008. Epub 2019 Aug 21.
To assess pubertal events in a Hispanic female population and to create normograms of puberty.
Longitudinal.
University facility.
Five hundred forty-nine girls from the Growth and Obesity Chilean Cohort study.
Follow-up twice a year beginning at age 6 years.
Breast development, pubic hair development, and age. Breast development (B2, B3, and B4) and pubarche (P2) were determined. Age at menarche was obtained from the adolescents and their mothers. Age and growth velocity at peak height velocity were calculated.
In girls, B2, B3, and B4 occur at median ages of 9.2, 10.2, and 10.9 years, respectively. The median age at P2 was 9.7 years. The mean age at peak height velocity and the growth velocity were 10.6 years (SD = 1.1) and 8 cm/y, respectively. The mean age at menarche was 11.9 years (SD = 1.1); only 2.8% (15 /530) of girls experienced menarche after 14 years and 1.9% before 10 years. The mean interval time between B2 and menarche was 2.5 ± 1.0 years. Transient thelarche occurred in 8.6% of girls.
This longitudinal cohort shows that thelarche occurred 1.2 months later than previously reported in cross-sectional studies. Conversely, we found that pubic hair appeared 12 months earlier and menarche occurred 9 months earlier than previously reported. These findings are important in setting normalcy data and avoiding unnecessary clinical consultations.
评估西班牙裔女性人群的青春期发育事件,并绘制青春期发育标准曲线。
纵向研究。
大学研究机构。
来自智利生长与肥胖队列研究的549名女孩。
从6岁开始每年随访两次。
乳房发育、阴毛发育和年龄。确定乳房发育(B2、B3和B4)和阴毛初现(P2)情况。月经初潮年龄由青少年及其母亲提供。计算身高生长速度峰值时的年龄和生长速度。
女孩中,B2、B3和B4分别在9.2岁、10.2岁和10.9岁的中位数年龄出现。P2的中位数年龄为9.7岁。身高生长速度峰值时的平均年龄和生长速度分别为10.6岁(标准差=1.1)和8厘米/年。月经初潮的平均年龄为11.9岁(标准差=1.1);只有2.8%(15/530)的女孩在14岁后经历月经初潮,1.9%在10岁前经历。B2到月经初潮的平均间隔时间为2.5±1.0年。8.6%的女孩出现过暂时性乳房增大。
该纵向队列研究表明,乳房开始发育的时间比之前横断面研究报道晚1.2个月。相反,我们发现阴毛出现时间比之前报道早12个月,月经初潮时间比之前报道早9个月。这些发现对于确定正常数据和避免不必要的临床咨询很重要。