Pereira Ana, Ferrer Pedro, Binder Alexandra, Rojas Joanna, Michels Karin B, Corvalán Camila, Mericq Verónica
Institute of Nutrition and Food Technology, University of Chile, 7830490 Santiago, Chile.
Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawai'i Cancer Center, Honolulu, HI 96822, USA.
J Clin Endocrinol Metab. 2023 Oct 18;108(11):e1272-e1281. doi: 10.1210/clinem/dgad294.
Prepubertal adiposity is associated with earlier puberty. It is unclear when this association starts, if all adiposity markers are similarly associated, and whether all pubertal milestones are similarly affected.
To evaluate the association between different adiposity markers during childhood and the timing of different pubertal milestones in Latino girls.
DESIGN, SETTING, AND PARTICIPANTS: Longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort recruited from childcare centers (mean age 3.5 years) from the southeast area of Santiago, Chile. Participants were singletons born between 2002 and 2003 within the normal birthweight range. Since 2006, a trained dietitian measured weight, height, waist circumference (WC) and skinfolds to estimate body mass index (BMI) Centers for Disease Control and Prevention percentiles, central obesity, percentage of fat mass (%FM), and fat mass index (FMI, fat mass/height2).
Since 2009, sexual maturation was assessed every 6 months to assess age at (1) thelarche, (2) pubarche, (3) menarche, and (4) peak height velocity (PHV).
At thelarche, 12.5% were obese and 2% had central obesity. The median age of pubarche, menarche, and PHV were all associated with markers of adiposity at different time points during childhood whereas thelarche only with %FM and FMI. Adiposity clusters models showed that children with trajectories of high WC, %FM, and FMI during childhood were related with earlier thelarche, pubarche, menarche, and PHV but BMI trajectories only with menarche and PHV.
Higher WC, %FM, and FMI were associated with earlier age at thelarche, pubarche, menarche, and PHV. The effect of BMI was less consistent.
青春期前肥胖与青春期提前有关。目前尚不清楚这种关联从何时开始，是否所有肥胖指标都有类似关联，以及所有青春期发育节点是否都受到类似影响。
评估拉丁裔女孩儿童期不同肥胖指标与不同青春期发育节点时间的关联。
设计、地点和参与者：对从智利圣地亚哥东南部地区的儿童保育中心招募的539名智利生长与肥胖队列女性参与者进行纵向随访（平均年龄3.5岁）。参与者为2002年至2003年出生的单胎，出生体重在正常范围内。自2006年起，由一名经过培训的营养师测量体重、身高、腰围（WC）和皮褶厚度，以估算体重指数（BMI）、美国疾病控制与预防中心百分位数、中心性肥胖、脂肪量百分比（%FM）和脂肪量指数（FMI，脂肪量/身高²）。
自2009年起，每6个月评估一次性成熟情况，以评估以下年龄：（1）乳房发育、（2）阴毛初现、（3）月经初潮和（4）身高增长高峰（PHV）。
乳房发育时，12.5%的女孩肥胖，2%有中心性肥胖。阴毛初现、月经初潮和身高增长高峰的中位年龄均与儿童期不同时间点的肥胖指标相关，而乳房发育仅与%FM和FMI相关。肥胖聚类模型显示，儿童期WC、%FM和FMI轨迹较高的儿童与乳房发育、阴毛初现、月经初潮和身高增长高峰提前有关，但BMI轨迹仅与月经初潮和身高增长高峰有关。
较高的WC、%FM和FMI与乳房发育、阴毛初现、月经初潮和身高增长高峰提前有关。BMI的影响不太一致。
