翼状胬肉组织中 CD44、PCNA 和 E-钙黏蛋白的表达。
Expression of CD44, PCNA and E-cadherin in pterygium tissues.
机构信息
Department of Ophthalmology, Balıkesir University, Faculty of Medicine, Balıkesir, Türkiye.
Department of Pathology, Balıkesir University, Faculty of Medicine, Balıkesir, Türkiye.
出版信息
Indian J Ophthalmol. 2024 May 1;72(Suppl 3):S501-S504. doi: 10.4103/IJO.IJO_2579_23. Epub 2024 Apr 20.
PURPOSE
Pterygium is a common ocular surface disease defined by fibrovascular conjunctival growth extending onto the cornea. However, its pathogenesis remains unclear. This study aimed to determine the role of CD44, proliferating cell nuclear antigen (PCNA), and E-cadherin in pterygium formation and recurrence.
METHODS
Sixty patients with pterygium participated in the study, and we collected conjunctival samples from 30 patients to form a control group. CD44, PCNA, and E-cadherin expressions in surgically excised pterygium were compared with tissue samples from the control group.
RESULTS
We observed that the percentages of CD44 and PCNA were statistically higher in the primary pterygium group and recurrent pterygium group than in the control group (P < 0.001 and P < 0.001, respectively). Conversely, E-cadherin values were statistically higher in the control group than in the primary and recurrent pterygium groups (P = 0.013 and P < 0.001, respectively).
CONCLUSION
Cell proliferation and cell adhesion factors may play important roles in the pathogenesis of pterygium.
目的
翼状胬肉是一种常见的眼表疾病，其特征为纤维血管结膜组织向角膜生长。然而，其发病机制尚不清楚。本研究旨在探讨 CD44、增殖细胞核抗原（PCNA）和 E-钙黏蛋白在翼状胬肉形成和复发中的作用。
方法
60 例翼状胬肉患者参与了本研究，我们从 30 例患者中采集了结膜样本作为对照组。比较了手术切除的翼状胬肉组织与对照组组织中 CD44、PCNA 和 E-钙黏蛋白的表达。
结果
我们发现原发性翼状胬肉组和复发性翼状胬肉组的 CD44 和 PCNA 百分比较对照组高（P<0.001 和 P<0.001）。相反，E-钙黏蛋白值在对照组中比原发性和复发性翼状胬肉组高（P=0.013 和 P<0.001）。
结论
细胞增殖和细胞黏附因子可能在翼状胬肉的发病机制中起重要作用。
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