翼状胬肉中YKL-40的表达：在发病机制中的潜在作用。
YKL-40 expression in pterygium: a potential role in the pathogenesis.
作者信息
Kurt Ali, Kılıç Raşit, Tad Murat, Polat Osman Ahmet
机构信息
Department of Ophthalmology, Faculty of Medicine, Ahi Evran University Medical School, Kırşehir, Turkey.
Training and Research Hospital, Ahi Evran University Medical School, Kayseri-Ankara Street, Kırşehir, Turkey.
出版信息
Int Ophthalmol. 2019 Jul;39(7):1445-1450. doi: 10.1007/s10792-018-0957-4. Epub 2018 Jun 19.
PURPOSE
The aim of the study was to evaluate whether YKL-40 (chitinase 3-like 1 protein) plays a role in pterygium pathogenesis.
METHODS
We included 42 primary pterygium patients and 24 control subjects with normal bulbar conjunctiva in the study. The pterygium patients were classified into the atrophic, fleshy, and intermediate groups according to the Tan classification. We then surgically removed the primary nasal pterygium and normal bulbar conjunctiva from the patients and immunohistochemically investigated YKL-40 expression.
RESULTS
YKL-40 expression was statistically significantly higher in the epithelial, endothelial, and stromal cells of the pterygium tissues than in the control tissues (P = 0.009, P = 0.003, P = 0.002, respectively). There was no significant correlation between the pterygium subgroups and YKL-40 expression (P > 0.05).
CONCLUSIONS
We believe YKL-40 may play a significant role in pterygium pathogenesis.
目的
本研究旨在评估YKL-40（几丁质酶3样1蛋白）在翼状胬肉发病机制中是否起作用。
方法
本研究纳入了42例原发性翼状胬肉患者和24例球结膜正常的对照受试者。根据Tan分类法，将翼状胬肉患者分为萎缩型、肉质型和中间型。然后，我们手术切除患者的原发性鼻侧翼状胬肉和正常球结膜，并通过免疫组织化学方法研究YKL-40的表达。
结果
翼状胬肉组织的上皮细胞、内皮细胞和基质细胞中的YKL-40表达在统计学上显著高于对照组织（分别为P = 0.009、P = 0.003、P = 0.002）。翼状胬肉亚组与YKL-40表达之间无显著相关性（P > 0.05）。
结论
我们认为YKL-40可能在翼状胬肉发病机制中起重要作用。
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