Epigenetics & Signalling Programmes, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: https://twitter.com/@azziChiA.
Epigenetics & Signalling Programmes, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Curr Opin Genet Dev. 2024 Jun;86:102197. doi: 10.1016/j.gde.2024.102197. Epub 2024 Apr 21.
Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited understanding of the molecular mechanisms that govern the duration and speed of developmental processes. Timing mechanisms may run in parallel and/or interact with each other to integrate temporal signals throughout the organism. In this piece, we consider findings on the extrinsic control of developmental tempo and discuss the intrinsic roles of cell cycle, metabolic rates, protein turnover, and post-transcriptional mechanisms in the regulation of tempo during neural development.
时间控制对于在发育过程中部署和协调遗传程序至关重要。目前，对于控制发育过程持续时间和速度的分子机制知之甚少。时间机制可能并行运行和/或相互作用，以在整个生物体中整合时间信号。在这篇文章中，我们考虑了发育节奏的外在控制的发现，并讨论了细胞周期、代谢率、蛋白质周转率和转录后机制在神经发育过程中对节奏调节的内在作用。
