Hardwick Laura J A, Philpott Anna
Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
Trends Genet. 2014 Jun;30(6):254-61. doi: 10.1016/j.tig.2014.04.001. Epub 2014 Apr 30.
The intricate balance between proliferation and differentiation is of fundamental importance in the development of the central nervous system (CNS). The division versus differentiation decision influences both the number and identity of daughter cells produced, thus critically shaping the overall microstructure and function of the CNS. During the past decade, significant advances have been made to characterise the changes in the cell cycle during differentiation, and to uncover the multiple bidirectional links that coordinate these two processes. Here, we explore the nature and mechanistic basis of these links in the context of the developing CNS, highlighting new insights into transcriptional, post-translational, and epigenetic levels of interaction.
增殖与分化之间的复杂平衡在中枢神经系统(CNS)的发育中至关重要。分裂与分化的决定影响所产生子细胞的数量和特性,从而对CNS的整体微观结构和功能产生关键影响。在过去十年中,在表征分化过程中细胞周期的变化以及揭示协调这两个过程的多个双向联系方面取得了重大进展。在此,我们在发育中的CNS背景下探讨这些联系的本质和机制基础,突出转录、翻译后和表观遗传水平相互作用的新见解。