Chen Cong, Liu Jian, Lin Xia, Xiang Aizhai, Ye Qianwei, Guo Jufeng, Rui Tao, Xu Jian, Hu Shufang
Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Department of Central Laboratory, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Cell Death Discov. 2024 Apr 22;10(1):189. doi: 10.1038/s41420-024-01958-9.
Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor microenvironment (TME), play multifaceted roles in cancer progression through paracrine signaling, exosome transfer, and cell interactions. Attractively, recent evidence indicates that CAFs can modulate various forms of regulated cell death (RCD) in adjacent tumor cells, thus involving cancer proliferation, therapy resistance, and immune exclusion. Here, we present a brief introduction to CAFs and basic knowledge of RCD, including apoptosis, autophagy, ferroptosis, and pyroptosis. In addition, we further summarize the different types of RCD in tumors that are mediated by CAFs, as well as the effects of these modes of RCD on CAFs. This review will deepen our understanding of the interactions between CAFs and RCD and might offer novel therapeutic avenues for future cancer treatments.
癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）的主要基质成分，通过旁分泌信号传导、外泌体转移和细胞相互作用在癌症进展中发挥多方面作用。引人注目的是，最近的证据表明，CAFs可以调节相邻肿瘤细胞中各种形式的程序性细胞死亡（RCD），从而涉及癌症增殖、治疗抗性和免疫排斥。在此，我们简要介绍CAFs和RCD的基础知识，包括细胞凋亡、自噬、铁死亡和焦亡。此外，我们进一步总结了由CAFs介导的肿瘤中不同类型的RCD，以及这些RCD模式对CAFs的影响。本综述将加深我们对CAFs与RCD之间相互作用的理解，并可能为未来的癌症治疗提供新的治疗途径。
