Chen Jiayuan, Ren Junyu, Wu Yingjie, Hu Narisu, Zhao Fang, Zhang Lin
First Affiliated Hospital of Harbin Medical University, College of Stomatology, Harbin Medical University No. 143 Yiman Street, Nangang District Harbin 150001 China
Oral Implant Center, Second Affiliated Hospital of Harbin Medical University, Harbin Medical University Harbin Heilongjiang China
RSC Adv. 2024 Apr 22;14(18):12935-12946. doi: 10.1039/d4ra01352b. eCollection 2024 Apr 16.
Oral mucosal impairment is a prevalent oral disease that frequently causes pain for patients. Conventional treatments have limited effectiveness and can cause adverse reactions. Furthermore, the moist and dynamic nature of the oral mucosal environment makes persistent adherence of conventional materials challenging, which can affect treatment efficacy. In this study, we investigated the potential of a NbC/TA-GelMA hydrogel system, where niobium carbide (NbC) and tannic acid (TA) were added to gelatin methacryloyl (GelMA), for repairing oral mucosal impairment. The wet adhesion properties of NbC/TA-GelMA hydrogels were confirmed by the inclusion of TA with a catechol-rich group. In addition, the photothermal effect of NbC/TA-GelMA hydrogel under near-infrared light, synergizing with TA, provided sustained antibacterial action. Furthermore, the NbC/TA-GelMA hydrogel effectively healed damaged oral mucosa of rats.
口腔黏膜损伤是一种常见的口腔疾病，常给患者带来疼痛。传统治疗方法效果有限且可能引起不良反应。此外，口腔黏膜环境的湿润和动态特性使得传统材料难以持续附着，这会影响治疗效果。在本研究中，我们研究了一种将碳化铌（NbC）和单宁酸（TA）添加到甲基丙烯酰化明胶（GelMA）中的NbC/TA-GelMA水凝胶体系修复口腔黏膜损伤的潜力。通过加入富含儿茶酚基团的TA证实了NbC/TA-GelMA水凝胶的湿粘附性能。此外，NbC/TA-GelMA水凝胶在近红外光下的光热效应与TA协同作用，提供了持续的抗菌作用。此外，NbC/TA-GelMA水凝胶有效地治愈了大鼠受损的口腔黏膜。
