The Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang University, Nanchang, Jiangxi, 330006, P.R. China.
The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P.R. China.
Biomater Sci. 2023 May 2;11(9):3180-3196. doi: 10.1039/d2bm01721k.
Oral mucosal ulcer is the most prevalent oral mucosal lesion, affecting the quality of life. Due to the moist and highly dynamic oral lining, the existing oral mucoadhesives are unable to serially address the challenges of residency, hemorrhage, bacterial infection and inflammatory reaction. Herein, a dual-light defined oral mucoadhesive (ZPTA-G/HMA) was proposed, with a methacrylate gelatin-methacrylate hyaluronic acid (GelMA-HAMA, G/HMA) double network hydrogel as a matrix, tannic acid (TA) as a high content anchor moiety provider for the moist oral mucosa, and polydopamine modified zinc oxide (ZnO@PDA, ZP) as a photocatalytic antibacterial substance. This platform had good adhesive and hemostatic properties both and . Under 520 nm green light (GL) irradiation, ZPTA-G/HMA would anchor to the wet mucosa surface by crosslinking and exert broad-spectrum antibacterial ability (even including ) by producing reactive oxygen species (ROS). Moreover, under 808 nm near-infrared (NIR) irradiation, the increased release of TA combined with the photothermal effect of ZP endowed ZPTA-G/HMA with enhanced anti-inflammatory and pro-healing performance. Collectively, ZPTA-G/HMA could be switched by light sources to achieve the dual-mode real-time adjustment of anti-bacterial function and controlled anti-inflammation, combined with ideal mucosal residence, thus promising in developing personalized sequential strategies for varied oral mucosal lesions.
口腔黏膜炎是最常见的口腔黏膜病变，影响生活质量。由于口腔衬里湿润且动态变化，现有的口腔黏附剂无法连续应对驻留、出血、细菌感染和炎症反应等挑战。在此，提出了一种双光定义的口腔黏附剂（ZPTA-G/HMA），以甲基丙烯酸明胶-甲基丙烯酸透明质酸（GelMA-HAMA，G/HMA）双网络水凝胶作为基质，单宁酸（TA）作为高含量的锚定部分提供者，用于湿润的口腔黏膜，以及聚多巴胺修饰的氧化锌（ZnO@PDA，ZP）作为光催化抗菌物质。该平台具有良好的黏附性和止血性能。在 520nm 绿光（GL）照射下，ZPTA-G/HMA 通过交联作用锚定在湿黏膜表面，并通过产生活性氧（ROS）发挥广谱抗菌能力（甚至包括 ）。此外，在 808nm 近红外（NIR）照射下，TA 的释放增加结合 ZP 的光热效应赋予了 ZPTA-G/HMA 增强的抗炎和促愈性能。总的来说，ZPTA-G/HMA 可以通过光源切换实现抗菌功能的双模式实时调节和控制抗炎，结合理想的黏膜驻留时间，有望为各种口腔黏膜病变开发个性化的序贯治疗策略。
