Voronina Alice K, Arapidi Georgij P
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
Front Microbiol. 2024 Apr 8;15:1371717. doi: 10.3389/fmicb.2024.1371717. eCollection 2024.
is a genus of spiral-shaped Gram-negative enterohepatic bacteria whose members are capable of causing bacteremia in humans. One of the poorly studied members of this genus is the bacterium . This microorganism was first isolated from human fecal samples in 1984. Although it was long considered to be associated with only immunocompromised patients, more evidence in recent years has implicated in causing serious pathologies in immunocompetent populations. In addition, is also reported to be associated with a few chronic or severe illnesses, such as atherosclerosis, which in turn can lead to the development of other cardiovascular pathologies: one of the leading causes of mortality worldwide. often goes unnoticed in standard diagnostic methods due to its slow growth under microaerobic conditions. This often leads to significant underdetection and hence undermines the role of this bacterium in the pathogenesis of various diseases and the extent of its spread in humans. In this review, we have compiled information on pathologies associated with , the occurrence of the bacterium in humans and animals, and the latest developments in diagnosing the bacterium and treating associated diseases.
是一种螺旋状革兰氏阴性肠肝菌属，其成员能够在人类中引起菌血症。该属中研究较少的成员之一是 细菌。这种微生物于1984年首次从人类粪便样本中分离出来。尽管长期以来人们认为它仅与免疫功能低下的患者有关，但近年来越来越多的证据表明 可在免疫功能正常的人群中引起严重病变。此外，据报道 还与一些慢性或严重疾病有关，如动脉粥样硬化，而动脉粥样硬化又可能导致其他心血管疾病的发展：这是全球主要的死亡原因之一。由于 在微需氧条件下生长缓慢，在标准诊断方法中常常被忽视。这往往导致大量漏检，从而削弱了这种细菌在各种疾病发病机制中的作用及其在人类中的传播程度。在这篇综述中，我们收集了有关 相关病变、该细菌在人类和动物中的出现情况以及诊断该细菌和治疗相关疾病的最新进展的信息。
