Hu Yuchi, Dai Songyuan, Zhao Lulu, Zhao Ling
Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Front Cardiovasc Med. 2024 Apr 8;11:1369343. doi: 10.3389/fcvm.2024.1369343. eCollection 2024.
Cardiovascular disease stands as a leading global cause of mortality. Nucleotide-binding Oligomerization Domain-like Receptor Protein 3 (NLRP3) inflammasome is widely acknowledged as pivotal factor in specific cardiovascular disease progression, such as myocardial infarction, heart failure. Recent investigations underscore a close interconnection between autonomic nervous system (ANS) dysfunction and cardiac inflammation. It has been substantiated that sympathetic nervous system activation and vagus nerve stimulation (VNS) assumes critical roles withinNLRP3 inflammasome pathway regulation, thereby contributing to the amelioration of cardiac injury and enhancement of prognosis in heart diseases. This article reviews the nexus between NLRP3 inflammasome and cardiovascular disorders, elucidating the modulatory functions of the sympathetic and vagus nerves within the ANS with regard to NLRP3 inflammasome. Furthermore, it delves into the potential therapeutic utility of NLRP3 inflammasome to be targeted by VNS. This review serves as a valuable reference for further exploration into the potential mechanisms underlying VNS in the modulation of NLRP3 inflammasome.
心血管疾病是全球主要的死亡原因。核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎性小体被广泛认为是特定心血管疾病进展的关键因素，如心肌梗死、心力衰竭。最近的研究强调了自主神经系统（ANS）功能障碍与心脏炎症之间的密切联系。已经证实，交感神经系统激活和迷走神经刺激（VNS）在NLRP3炎性小体途径调节中起关键作用，从而有助于减轻心脏损伤并改善心脏病的预后。本文综述了NLRP3炎性小体与心血管疾病之间的联系，阐明了自主神经系统中交感神经和迷走神经对NLRP3炎性小体的调节功能。此外，还探讨了以VNS为靶点的NLRP3炎性小体的潜在治疗效用。本综述为进一步探索VNS调节NLRP3炎性小体的潜在机制提供了有价值的参考。
