Department of Rehabilitation, Breast Care Sensyu Clinic, Osaka, Japan.
Division of Rehabilitation Medicine, Kobe University Hospital International Clinical Cancer Research Center, Hyogo, Japan.
Support Care Cancer. 2024 Apr 23;32(5):304. doi: 10.1007/s00520-024-08504-4.
Chemotherapy-induced peripheral neuropathy (CIPN) commonly involves hand dexterity impairment. However, the factors affecting hand dexterity impairment are unknown and there is currently no established treatment. The purpose of the current study was to clarify factors influencing hand dexterity impairment in taxane-induced peripheral neuropathy using subjective and objective assessments.
We assessed patient characteristics, treatment-related factors, subjective symptoms of CIPN (Patient Neurotoxicity Questionnaire [PNQ]), psychological symptoms, and upper limb dysfunction (Quick Disabilities of the Arm, Shoulder and Hand [Quick DASH]). Quantitative assessments were pinch strength, sensory threshold, hand dexterity impairment, and grip force control. Multiple regression analysis was performed using hand dexterity impairment as the dependent variable and age and PNQ, Quick DASH, and control of grip force as independent variables.
Forty-three breast cancer patients were included in the analysis. Hand dexterity impairment in taxane-induced peripheral neuropathy patients was significantly correlated with age, grip force control, and PNQ sensory scores (p < 0.008). Multiple regression analysis demonstrated that PNQ sensory scores and grip force control were significantly associated with hand dexterity impairment (p < 0.01).
Subjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy.
化疗引起的周围神经病（CIPN）通常会导致手部灵巧度受损。然而，影响手部灵巧度受损的因素尚不清楚，目前也没有确立的治疗方法。本研究的目的是使用主观和客观评估来阐明紫杉烷类药物引起的周围神经病中影响手部灵巧度受损的因素。
我们评估了患者特征、治疗相关因素、CIPN 的主观症状（患者神经毒性问卷 [PNQ]）、心理症状以及上肢功能障碍（快速上肢、肩部和手部残疾问卷 [Quick DASH]）。定量评估包括捏力、感觉阈值、手部灵巧度受损和握力控制。使用手部灵巧度受损作为因变量，年龄和 PNQ、Quick DASH 和握力控制作为自变量进行多元回归分析。
共纳入 43 例乳腺癌患者进行分析。紫杉烷类药物引起的周围神经病患者的手部灵巧度受损与年龄、握力控制和 PNQ 感觉评分显著相关（p<0.008）。多元回归分析表明，PNQ 感觉评分和握力控制与手部灵巧度受损显著相关（p<0.01）。
主观症状（麻木和疼痛）和握力控制与紫杉烷类药物引起的周围神经病中的手部灵巧度受损有关。
