Chen Yinyu, Liu Jiaqi, Song Tao, Zou Xing, Li Leilei, Nie Qianyun, Zhang Peng
Department of Forensic Medicine, Hainan Provincial Tropical Forensic Engineering Research Center, Hainan Provincial Academician Workstation (tropical forensic medicine), Hainan Medical University, Haikou, China.
Department of Neurology, the First Affiliated Hospital, International School of Public Health and One Health, Hainan Medical University, Haikou, China.
Forensic Sci Med Pathol. 2024 Dec;20(4):1453-1457. doi: 10.1007/s12024-024-00813-8. Epub 2024 Apr 23.
Etomidate is a nonbarbiturate sedative derived from imidazole. Prolonged and excessive use of etomidate can lead to the suppression of adrenocortical function, myoclonus, and even death. This report describes a rare case of a 47-year-old man who died from acute intoxication after oral ingestion of liquid containing etomidate. The cause of death was conclusively attributed to etomidate based on a comprehensive investigation, including autopsy, histopathological examination, toxicological analysis, and biochemical analysis. This is the first reported case of a fatality solely resulting from the oral ingestion of etomidate, which can provide valuable insights for future forensic investigations involving etomidate poisoning. Therefore, it is imperative to share this case with the scientific community.
依托咪酯是一种源自咪唑的非巴比妥类镇静剂。长期过量使用依托咪酯可导致肾上腺皮质功能抑制、肌阵挛,甚至死亡。本报告描述了一例罕见病例,一名47岁男子因口服含依托咪酯的液体后急性中毒死亡。基于包括尸检、组织病理学检查、毒理学分析和生化分析在内的全面调查,死亡原因最终确定为依托咪酯。这是首例仅因口服依托咪酯导致死亡的报告病例,可为未来涉及依托咪酯中毒的法医调查提供有价值的见解。因此,必须与科学界分享此病例。