Mo Yan, Zhang Xiaoping, Zou Ke, Xing Wen, Hou Xiayang, Zeng Yu, Cai Yugang, Xu Ruixiang, Zhang Hongwen, Cai Weiping
Intelligent Policing Key Laboratory of Sichuan Province, Sichuan Police College, Luzhou 646000, China.
Anhui Xianghe Environmental Testing Co., Ltd., Huaibei 235100, China.
Nanomaterials (Basel). 2024 Dec 6;14(23):1958. doi: 10.3390/nano14231958.
Etomidate (ET), a medical anesthetic, is increasingly being incorporated into e-liquids for consumption and abuse as a new psychoactive substance (NPS), leading to significant social issues. In this work, large-area Au micro- and nano-structured ordered arrays were engineered as surface-enhanced Raman spectroscopy (SERS) substrates for fast detection and precise identification of ET and its metabolites. This ordered array, characterized by abundant electromagnetic enhancement hotspots and structural uniformity, imparts unique properties to the SERS substrate, including ultra-sensitivity, spectral signal reproducibility, and precise quantitative capabilities. Furthermore, it effectively mitigates interference from the complex matrix of e-liquids, facilitating the rapid detection of trace amounts of ET molecules. This SERS rapid detection technology can act as a preliminary screening method for gold-standard spectroscopic analysis, facilitating the on-site rapid screening of suspicious samples and thereby enabling efficient detection and precise verification.
依托咪酯（ET）是一种医用麻醉剂，越来越多地作为新型精神活性物质（NPS）被掺入电子烟液中以供消费和滥用，从而引发了严重的社会问题。在这项工作中，大面积的金微纳结构有序阵列被设计为表面增强拉曼光谱（SERS）基底，用于快速检测和精确识别ET及其代谢物。这种有序阵列具有丰富的电磁增强热点和结构均匀性，赋予了SERS基底独特的性能，包括超灵敏度、光谱信号重现性和精确的定量能力。此外，它有效地减轻了电子烟液复杂基质的干扰，便于快速检测痕量的ET分子。这种SERS快速检测技术可作为金标准光谱分析的初步筛选方法，便于对可疑样品进行现场快速筛选，从而实现高效检测和精确验证。
