Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolia Medical University, PR China.
College of Basic Medicine, Inner Mongolia Medical University, PR China; Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University, PR China.
Biomed Pharmacother. 2024 Jun;175:116620. doi: 10.1016/j.biopha.2024.116620. Epub 2024 Apr 22.
There is a growing interest in the role of the miRNA family in human cancer. The miRNA-192 family is a group of conserved small RNAs, including miR-192, miR-194, and miR-215. Recent studies have shown that the incidence and mortality of breast cancer have been increasing epidemiologically year by year, and it is urgent to clarify the pathogenesis of breast cancer and seek new diagnostic and therapeutic methods. There is increasing evidence that miR-192 family members may be involved in the occurrence and development of breast cancer. This review describes the regulatory mechanism of the miRNA-192 family affecting the malignant behavior of breast cancer cells and evaluates the value of the miRNA-192 family as a diagnostic and prognostic biomarker for breast cancer. It is expected that summarizing and discussing the relationship between miRNA-192 family members and breast cancer, it will provide a new direction for the clinical diagnosis and treatment of breast cancer and basic medical research.
miRNA-192 家族在人类癌症中的作用引起了越来越多的关注。miRNA-192 家族是一组保守的小 RNA，包括 miR-192、miR-194 和 miR-215。最近的研究表明，乳腺癌的发病率和死亡率在流行病学上逐年增加，迫切需要阐明乳腺癌的发病机制并寻求新的诊断和治疗方法。越来越多的证据表明，miR-192 家族成员可能参与乳腺癌的发生和发展。本综述描述了 miRNA-192 家族调节机制影响乳腺癌细胞恶性行为，并评估了 miRNA-192 家族作为乳腺癌诊断和预后生物标志物的价值。期望通过总结和讨论 miRNA-192 家族成员与乳腺癌之间的关系，为乳腺癌的临床诊断和治疗以及基础医学研究提供新的方向。
