Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Food Hygiene and Public Health Department, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Breast Cancer. 2018 Mar;25(2):198-205. doi: 10.1007/s12282-017-0814-8. Epub 2017 Nov 3.
Breast cancer (BC) is the most prevalent cancer and the main cause of cancer deaths among females around the world. For early diagnosis of BC, there would be an immediate and essential requirement to search for sensitive biomarkers.
To identify candidate miRNA biomarkers for BC, we performed a general systematic review regarding the published miRNA profiling researches comparing miRNA expression level between BC and normal tissues. A miRNA ranking system was selected, which considered frequency of comparisons in direction and agreement of differential expression.
We determined that two miRNAs (mir-21 and miR-210) were upregulated consistently and six miRNAs (miR-145, miR-139-5p, miR-195, miR-99a, miR-497 and miR-205) were downregulated consistently in at least three studies. MiR-21 as the most consistently reported miRNA was upregulated in six profiling studies.
Although these miRNAs require being validated and further investigated, they could be potential candidates for BC miRNA biomarkers and used for early prognosis or diagnosis.
乳腺癌（BC）是全球女性中最常见的癌症和癌症死亡的主要原因。为了实现 BC 的早期诊断，我们迫切需要寻找灵敏的生物标志物。
为了鉴定用于 BC 的候选 miRNA 生物标志物，我们对已发表的 miRNA 谱分析研究进行了全面的系统回顾，这些研究比较了 BC 与正常组织之间的 miRNA 表达水平。我们选择了 miRNA 排序系统，该系统考虑了比较方向的频率和差异表达的一致性。
我们确定了两个 miRNA（miR-21 和 miR-210）在至少三项研究中一致上调，六个 miRNA（miR-145、miR-139-5p、miR-195、miR-99a、miR-497 和 miR-205）在至少三项研究中一致下调。miR-21 作为报道最一致的 miRNA，在六项分析研究中上调。
尽管这些 miRNA 需要进一步验证和研究，但它们可能是用于 BC miRNA 生物标志物的潜在候选物，并可用于早期预后或诊断。
