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对非洲的(胡克. F.)卡尔克曼的民族药用用途、植物化学、药理学及毒性的综合综述

A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of (Hook. F.) Kalkman from Africa.

作者信息

Ndung'u James K, Nguta Joseph M, Mapenay Isaac M, Moriasi Gervason A

机构信息

Department of Public Health, Pharmacology, and Toxicology, University of Nairobi, P.O. Box 29053-00625, Nairobi, Kenya.

Department of Pharmacy, Kenya Medical Training College, Nakuru Campus Kenya, P.O. Box 110, Nakuru, Kenya.

出版信息

Scientifica (Cairo). 2024 Apr 16;2024:8862996. doi: 10.1155/2024/8862996. eCollection 2024.

Abstract

, a widely utilized medicinal plant in various African ethnic communities, continues to hold significant importance in traditional healing practices. Research has identified phytochemical compounds in this plant, exhibiting diverse pharmacological activities that offer potential for pharmaceutical development. Notably, is employed in treating various ailments such as wounds, diabetes mellitus, malaria, benign prostatic hyperplasia, chest pain, and prostate cancer. Its pharmacological properties are attributed to a spectrum of bioactive compounds, including tannins, saponins, alkaloids, flavonoids, terpenoids, phytosterols, and fatty acids. Multiple studies have documented the anti-inflammatory, antimicrobial, antiandrogenic, antiangiogenic, antioxidant, antidipeptidyl peptidase-4 activity, analgesic, and astringent properties of extracts. This review offers a comprehensive compilation of ethnomedicinal applications, phytochemical composition, pharmacological effects, and toxicity assessments of , serving as a foundation for future preclinical and clinical investigations. By understanding its traditional uses and chemical constituents, researchers can target specific medical conditions with greater precision, potentially expediting the development of safe and effective pharmaceuticals. Moreover, toxicity assessments provide crucial insights into the safety profile of extracts, ensuring the development of safe pharmaceuticals to treat various diseases.

摘要

作为一种在非洲各民族社区广泛使用的药用植物,在传统治疗方法中仍然具有重要意义。研究已经在这种植物中鉴定出植物化学成分,这些成分表现出多种药理活性,为药物开发提供了潜力。值得注意的是,它被用于治疗各种疾病,如伤口、糖尿病、疟疾、良性前列腺增生、胸痛和前列腺癌。其药理特性归因于一系列生物活性化合物,包括单宁、皂苷、生物碱、黄酮类化合物、萜类化合物、植物甾醇和脂肪酸。多项研究记录了该植物提取物的抗炎、抗菌、抗雄激素、抗血管生成、抗氧化、抗二肽基肽酶 -4 活性、镇痛和收敛特性。本综述全面汇编了该植物的民族药用应用、植物化学成分、药理作用和毒性评估,为未来的临床前和临床研究奠定了基础。通过了解其传统用途和化学成分,研究人员可以更精确地针对特定医疗状况,有可能加快安全有效的药物开发。此外,毒性评估为该植物提取物的安全性提供了关键见解,确保开发出治疗各种疾病的安全药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90a8/11039028/94076f89ec40/SCIENTIFICA2024-8862996.001.jpg

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