Komakech Richard, Kang Youngmin, Lee Jun-Hwan, Omujal Francis
University of Science & Technology (UST), Korean Medicine Life Science, Daejeon 34054, Republic of Korea; Korea Institute of Oriental Medicine (KIOM), Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea; Natural Chemotherapeutics Research Institute (NCRI), Ministry of Health, P.O. Box 4864, Kampala, Uganda.
University of Science & Technology (UST), Korean Medicine Life Science, Daejeon 34054, Republic of Korea; Korea Institute of Oriental Medicine (KIOM), Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea.
Evid Based Complement Alternat Med. 2017;2017:3014019. doi: 10.1155/2017/3014019. Epub 2017 Feb 13.
Prostate cancer remains one of the major causes of death worldwide. In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease. Recent evidence supports the beneficial effects of plant-derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer. has been used for generations in African traditional medicine to treat prostate cancer. This review examined the potential roles of the phytochemicals from , an endangered, sub-Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer. In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of -derived phytochemicals. Through synergistic interactions between different effective phytochemicals, extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells. However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.
前列腺癌仍然是全球主要死因之一。鉴于前列腺癌患者的治疗选择有限，基于天然化合物的预防和治疗方法在应对这种疾病方面可以发挥不可或缺的作用。最近的证据支持植物源植物化学物质作为包括前列腺癌在内的各种癌症的化学预防和化疗药物的有益作用。[某种植物]在非洲传统医学中已被使用数代来治疗前列腺癌。本综述研究了一种来自撒哈拉以南非洲的濒危植物[某种植物]中的植物化学物质在前列腺癌化学预防和化疗中的潜在作用。体外和体内研究为[某种植物]衍生的植物化学物质抗前列腺癌活性提供了有力的药理学证据。通过不同有效植物化学物质之间的协同相互作用，[某种植物]提取物已显示出非常强的抗雄激素和抗血管生成活性，并且有能力通过凋亡途径杀死肿瘤细胞，防止前列腺癌细胞增殖，并改变维持前列腺癌细胞所需的信号通路。然而，应该进行进一步的临床前和临床研究，以推进并最终将这些有前景的植物化学物质用于人类前列腺癌的预防和化疗。
