Mack R E, Yagiela J A
Anesth Prog. 1985 Jul-Aug;32(4):147-50.
The effect of pretreatment with 20 mg/kg sodium pentobarbital on the acute intravenous toxicity of 2% lidocaine was determined in rats. Pretreatment increased the LD(50) of lidocaine from 20.2 mg/kg to 26.9 mg/kg (p<0.05). This 25% decrease in lethality was accompanied by similar decreases in the concentrations of lidocaine (relative to the injected dose) in serum and brainstem samples collected immediately after death. Under the conditions of this study, pentobarbital apparently protects against lidocaine lethality by increasing the relative distribution of local anesthetic to tissues outside of the central nervous system.
在大鼠中测定了用20mg/kg戊巴比妥钠预处理对2%利多卡因急性静脉毒性的影响。预处理使利多卡因的半数致死量（LD50）从20.2mg/kg增加到26.9mg/kg（p<0.05）。致死率降低25%的同时，死亡后立即采集的血清和脑干样本中利多卡因浓度（相对于注射剂量）也出现了类似程度的降低。在本研究条件下，戊巴比妥钠显然是通过增加局部麻醉药在中枢神经系统以外组织中的相对分布来预防利多卡因致死的。
