School of Stomatology, Zunyi Medical University, Zunyi, China.
Department of Orthodontics, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Oral Dis. 2024 Oct;30(7):4087-4097. doi: 10.1111/odi.14970. Epub 2024 Apr 24.
Periodontitis can lead to the destruction of periodontal tissues and potentially tooth loss. Numerous periodontal tissue-derived cells display osteogenic differentiation potential. The presence of differentially expressed long non-coding RNAs (lncRNAs) in these cells indicate their ability to regulate the process of osteogenic differentiation. We aim to elucidate the various lncRNA-mediated regulatory mechanisms in the osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis at epigenetic modification, transcriptional, and post-transcriptional levels.
We systematically searched the PubMed, Web of Science, and ScienceDirect databases to identify relevant literature in the field of periodontitis discussing the role of lncRNAs in regulating osteogenic differentiation of periodontal tissue-derived cells. The identified literature was subsequently summarized for comprehensive review.
In this review, we have comprehensively summarized the regulatory mechanisms of lncRNAs in the osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis and discussed how these lncRNAs provide novel perspectives for understanding the pathogenesis and progression of periodontitis.
These results indicate the pivotal role of lncRNAs as regulators in the osteogenic differentiation of periodontal tissue-derived cells, providing a solid basis for future investigations on the role of lncRNAs in the periodontitis field.
牙周炎可导致牙周组织破坏，并可能导致牙齿丧失。许多牙周组织来源的细胞显示出成骨分化潜能。这些细胞中存在差异表达的长链非编码 RNA（lncRNA）表明它们能够调节成骨分化过程。我们旨在阐明在牙周炎领域中，在表观遗传修饰、转录和转录后水平上，牙周组织来源的细胞的成骨分化中各种 lncRNA 介导的调节机制。
我们系统地检索了 PubMed、Web of Science 和 ScienceDirect 数据库，以确定牙周炎领域中讨论 lncRNA 调节牙周组织来源的细胞成骨分化作用的相关文献。随后对确定的文献进行了总结，以进行全面综述。
在本综述中，我们全面总结了 lncRNA 在牙周炎领域中牙周组织来源的细胞成骨分化中的调节机制，并讨论了这些 lncRNA 如何为理解牙周炎的发病机制和进展提供新的视角。
这些结果表明 lncRNA 作为调节因子在牙周组织来源的细胞成骨分化中发挥着关键作用，为未来在牙周炎领域研究 lncRNA 的作用提供了坚实的基础。
