Zhu Yinci, Guan Xiaoyan, Geng Xiaorui, Du Yuanhang, Jin Suhan, Liu Jianguo
School of Stomatology, Zunyi Medical University, Zunyi, China.
Department of Orthodontics, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
J Periodontal Res. 2024 Feb;59(1):18-31. doi: 10.1111/jre.13199. Epub 2023 Nov 14.
Periodontitis is a prevalent oral disease caused by chronic inflammation of the periodontal tissues surrounding the teeth, which can lead to bone loss, tooth loosening, and even tooth loss. This inflammation has a negative impact on the osteogenic differentiation capacity of periodontal tissue-derived cells. Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but can regulate various physiological processes. In this review, we summarized the critical signaling pathways that ncRNAs modulate in osteogenic differentiation of periodontal tissue-derived cells, such as the Wnt, BMP/Smad, NF-κB, and PI3-K/Akt/mTOR pathways. This comprehensive exploration of ncRNA-mediated modulation offers fresh and promising insights for prospective approaches in the management of periodontitis and the advancement of periodontal regeneration therapies.
牙周炎是一种常见的口腔疾病，由牙齿周围牙周组织的慢性炎症引起，可导致骨质流失、牙齿松动甚至牙齿脱落。这种炎症对牙周组织来源细胞的成骨分化能力有负面影响。非编码RNA（ncRNAs）是一类不编码蛋白质但可调节各种生理过程的RNA分子。在本综述中，我们总结了ncRNAs在牙周组织来源细胞成骨分化中调节的关键信号通路，如Wnt、BMP/Smad、NF-κB和PI3-K/Akt/mTOR通路。对ncRNA介导调节的这种全面探索为牙周炎管理的前瞻性方法和牙周再生治疗的进展提供了新的、有前景的见解。
