Department of Biochemistry, Integral Institute of Medical Sciences & Research (IIMSR), Integral University, Lucknow, Uttar Pradesh- 226026, India.
Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences & Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh-226026, India.
Endocr Regul. 2024 Apr 24;58(1):83-90. doi: 10.2478/enr-2024-0009. Print 2024 Jan 1.
Abnormal lipid profile and obesity increase the risk of polycystic ovary syndrome (PCOS). PCOS patients may have a greater risk of infertility, metabolic syndrome (MetS) and cardiovascular disease (CVD) due to abnormal lipid profile and obesity. The aim of the study was to find the association between abnormal lipid profile and obesity in patients with PCOS. In this case-control study, a total of 102 female subjects (51 diagnosed PCOS and 51 age-matched healthy controls) were enrolled, aged between 20-40 years. Biochemical parameters such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), very low-density lipoprotein-cholesterol (VLDL-C), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were estimated. Anthropometric parameters such as body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were recorded. A p<0.05 was considered statistically significant. Mean of BMI, WC, WHR, LH, FSH, TC, TG, LDL-C, and VLDL-C was found significantly elevated in patients with PCOS as compared to controls (p<0.01). However, the mean of HDL-C was found significantly reduced in patients with PCOS as compared to controls (p<0.01). BMI has shown a significant positive correlation with WC (r=0.562, p<0.01) and WHR (r=0.580, p<0.01) among PCOS patients. LH has shown a significant positive correlation with FSH (r=0.572, p<0.01) among PCOS patients. TC has shown a significant positive correlation with TG (r=0.687, p<0.01), LDL-C (r=0.917, p<0.01), and VLDL-C (r=0.726, p<0.01) among PCOS patients. The results showed that abnormal lipid profile and obesity have a significant association with PCOS patients. Regular monitoring and treatment of PCOS patients are required to reduce the risk of infertility, MetS, and CVD.
异常的血脂水平和肥胖会增加多囊卵巢综合征（PCOS）的风险。由于血脂异常和肥胖，PCOS 患者可能面临更高的不孕、代谢综合征（MetS）和心血管疾病（CVD）风险。本研究旨在探讨 PCOS 患者血脂异常和肥胖之间的相关性。 在这项病例对照研究中，共纳入了 102 名女性受试者（51 名确诊为 PCOS，51 名年龄匹配的健康对照组），年龄在 20-40 岁之间。测定了总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、黄体生成素（LH）和卵泡刺激素（FSH）等生化参数。记录了体重指数（BMI）、腰围（WC）、臀围（HC）和腰臀比（WHR）等人体测量参数。p<0.05 被认为具有统计学意义。 与对照组相比，PCOS 患者的 BMI、WC、WHR、LH、FSH、TC、TG、LDL-C 和 VLDL-C 均值显著升高（p<0.01）。然而，PCOS 患者的 HDL-C 均值显著降低（p<0.01）。在 PCOS 患者中，BMI 与 WC（r=0.562，p<0.01）和 WHR（r=0.580，p<0.01）呈显著正相关。LH 与 FSH 之间呈显著正相关（r=0.572，p<0.01）。在 PCOS 患者中，TC 与 TG（r=0.687，p<0.01）、LDL-C（r=0.917，p<0.01）和 VLDL-C（r=0.726，p<0.01）呈显著正相关。 结果表明，异常的血脂水平和肥胖与 PCOS 患者显著相关。需要对 PCOS 患者进行定期监测和治疗，以降低不孕、MetS 和 CVD 的风险。
