Department of Cardiology, Leiden University Medical Center, Leiden.
Department of Cardiology, Medical Center Haaglanden, The Hague.
Coron Artery Dis. 2024 Aug 1;35(5):405-412. doi: 10.1097/MCA.0000000000001364. Epub 2024 Apr 25.
Cardiovascular disease (CVD) imposes a major healthcare burden on young descendants of South Asian migrants living in the western world. In comparison to the native population, the prevalence is significantly higher and the prevalence of CVD risk factors is increasing rapidly. The cardiovascular risk profile and 10-year risk scores of South Asian descendants were evaluated in two cohorts with a 10-year time difference.
Two cross-sectional studies, conducted in 2004 and 2014, focused on asymptomatic South Asian descendants aged 18-59 years were performed. A short questionnaire, BMI, waist circumference, blood pressure, and nonfasting blood tests were obtained. The cohort of 2014 was matched with the cohort of 2004, based on age, gender, and family history of CVD.
In 2014, 674 South Asians (44% men, age 38.2 ± 12.0 years) were matched with 674 South Asians (44% men, age 38.3 ± 12.1 years) included in 2004. Notably, hypertension prevalence decreased significantly in 2014 (10.6% vs 23.1% in 2004, P < 0.001), while mean BMI increased (26.1 vs 24.9, P < 0.001). The mean Framingham risk score was lower in 2014 (5.31 ± 6.19%) than in 2004 (6.45 ± 8.02%, P < 0.05).
This study demonstrates that South Asian descendants in 2014 have a lower but still high absolute risk for coronary events compared to 2004. Important differences in cardiovascular risk profile exist. Despite improvements, South Asian descendants in 2014 still face a high absolute risk for coronary events compared to 2004, indicating the necessity for continued primary prevention and lifestyle interventions.
心血管疾病（CVD）给生活在西方世界的南亚移民的年轻后代带来了重大的医疗保健负担。与本地人口相比，南亚移民后代的患病率明显更高，且 CVD 风险因素的患病率正在迅速上升。本研究评估了两代南亚移民后代之间相隔 10 年的心血管风险概况和 10 年风险评分。
本研究共进行了两项横断面研究，纳入了 2004 年和 2014 年的无症状南亚移民后代（年龄 18-59 岁）。收集了简短的问卷、BMI、腰围、血压和非空腹血液检查等数据。2014 年的队列与 2004 年的队列根据年龄、性别和 CVD 家族史进行匹配。
2014 年，有 674 名南亚人（44%为男性，年龄 38.2±12.0 岁）与 2004 年的 674 名南亚人（44%为男性，年龄 38.3±12.1 岁）进行了匹配。值得注意的是，2014 年高血压的患病率显著下降（10.6% vs. 23.1%，P<0.001），而平均 BMI 则有所增加（26.1 与 24.9，P<0.001）。2014 年Framingham 风险评分（5.31±6.19%）低于 2004 年（6.45±8.02%，P<0.05）。
本研究表明，与 2004 年相比，2014 年的南亚移民后代的冠心病事件绝对风险仍然较高，但有所降低。心血管风险概况存在重要差异。尽管有所改善，但与 2004 年相比，2014 年的南亚移民后代仍然面临较高的冠心病事件绝对风险，这表明需要继续进行一级预防和生活方式干预。
